PMID- 25145986
OWN - NLM
STAT- MEDLINE
DCOM- 20150611
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 10
DP  - 2014 Oct
TI  - Efficacy and safety of house dust mite sublingual immunotherapy in monosensitized 
      and polysensitized children with respiratory allergic diseases.
PG  - 796-801
LID - 10.1002/alr.21397 [doi]
AB  - BACKGROUND: The efficacy of single-allergen-specific immunotherapy in 
      polysensitized subjects is a matter of debate. This study aimed to investigate 
      the efficacy of house dust mite (HDM) sublingual immunotherapy (SLIT) in 
      monosensitized and polysensitized children. METHODS: A total of 112 children, 
      aged 4 to 13 years old, with HDM-induced respiratory allergic diseases were 
      allocated to a monosensitized group (n = 56) or a polysensitized group (n = 56). 
      Both groups were treated by standard pharmacotherapy and SLIT with 
      Dermatophagoides farinae (American HDM) extracts for 52 weeks. Symptoms, 
      medications, visual analogue scale (VAS), and presence of adverse events (AEs) 
      were assessed once a month. Skin-prick test (SPT) was done before and after 
      treatment. After treatment, subjects in the polysensitized group who completed 
      the study were further analyzed as subgroup 1 (n = 20) and subgroup 2 (n = 15) 
      according to the number of coexisting allergens. RESULTS: Forty-one subjects in 
      the monosensitized group and 35 subjects in the polysensitized group completed 
      the study. The global clinical parameters had significantly improved after 
      treatment, with no significant difference between the monosensitized and 
      polysensitized group throughout this period (all p > 0.05). The comparison among 
      the monosensitized group, subgroup 1, and subgroup 2 indicated that there was no 
      significant difference in symptoms scores and VAS at each scheduled follow-up 
      visit. There was also no significant difference in total medications score (TMS) 
      in the monosensitized group, subgroup 1, and subgroup 2 after week 24 (all p > 
      0.05). No severe systemic AEs were reported. CONCLUSION: No significant 
      difference was observed in the clinical effects of HDM SLIT between 
      polysensitized and monosensitized children with respiratory allergic diseases.
CI  - (c) 2014 ARS-AAOA, LLC.
FAU - Li, Peng
AU  - Li P
AD  - Department of Otorhinolaryngology, Nanjing Children's Hospital Affiliated to 
      Nanjing Medical University, Jiangsu, P.R. China.
FAU - Li, Qi
AU  - Li Q
FAU - Huang, Zhenghua
AU  - Huang Z
FAU - Chen, Wenbo
AU  - Chen W
FAU - Lu, Yueqian
AU  - Lu Y
FAU - Tian, Man
AU  - Tian M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140821
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Animals
MH  - Asthma/immunology/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunization/adverse effects/*methods
MH  - Male
MH  - Prospective Studies
MH  - Pyroglyphidae/*immunology
MH  - Rhinitis, Allergic/immunology/*therapy
MH  - Skin Tests
MH  - Sublingual Immunotherapy/adverse effects/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Allergy
OT  - efficacy
OT  - monosensitized
OT  - polysensitized
OT  - sublingual immunotherapy
EDAT- 2014/08/26 06:00
MHDA- 2015/06/13 06:00
CRDT- 2014/08/23 06:00
PHST- 2014/04/22 00:00 [received]
PHST- 2014/06/18 00:00 [revised]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/08/23 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - 10.1002/alr.21397 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 Oct;4(10):796-801. doi: 10.1002/alr.21397. Epub 
      2014 Aug 21.