PMID- 25146174
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20211021
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 90
DP  - 2014 Aug 5
TI  - Network analysis of the default mode network using functional connectivity MRI in 
      Temporal Lobe Epilepsy.
PG  - e51442
LID - 10.3791/51442 [doi]
LID - 51442
AB  - Functional connectivity MRI (fcMRI) is an fMRI method that examines the 
      connectivity of different brain areas based on the correlation of BOLD signal 
      fluctuations over time. Temporal Lobe Epilepsy (TLE) is the most common type of 
      adult epilepsy and involves multiple brain networks. The default mode network 
      (DMN) is involved in conscious, resting state cognition and is thought to be 
      affected in TLE where seizures cause impairment of consciousness. The DMN in 
      epilepsy was examined using seed based fcMRI. The anterior and posterior hubs of 
      the DMN were used as seeds in this analysis. The results show a disconnection 
      between the anterior and posterior hubs of the DMN in TLE during the basal state. 
      In addition, increased DMN connectivity to other brain regions in left TLE along 
      with decreased connectivity in right TLE is revealed. The analysis demonstrates 
      how seed-based fcMRI can be used to probe cerebral networks in brain disorders 
      such as TLE.
FAU - Haneef, Zulfi
AU  - Haneef Z
AD  - Department of Neurology, Baylor College of Medicine; Neurology Care Line, Michael 
      E. DeBakey VA Medical Center; Zulfi.Haneef@bcm.edu.
FAU - Lenartowicz, Agatha
AU  - Lenartowicz A
AD  - Semel Institute for Neuroscience and Human Behavior, University of California, 
      Los Angeles.
FAU - Yeh, Hsiang J
AU  - Yeh HJ
AD  - Department of Neurology, University of California, Los Angeles.
FAU - Engel, Jerome Jr
AU  - Engel J Jr
AD  - Department of Neurology, University of California, Los Angeles.
FAU - Stern, John M
AU  - Stern JM
AD  - Department of Neurology, University of California, Los Angeles.
LA  - eng
GR  - K23 NS044936/NS/NINDS NIH HHS/United States
GR  - P01 NS002808/NS/NINDS NIH HHS/United States
GR  - R01 NS033310/NS/NINDS NIH HHS/United States
GR  - U01 NS042372/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20140805
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Case-Control Studies
MH  - Epilepsy, Temporal Lobe/pathology/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Nerve Net/pathology/*physiopathology
PMC - PMC4448548
EDAT- 2014/08/26 06:00
MHDA- 2015/02/24 06:00
PMCR- 2015/08/05
CRDT- 2014/08/23 06:00
PHST- 2014/08/23 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
PHST- 2015/08/05 00:00 [pmc-release]
AID - 51442 [pii]
AID - 10.3791/51442 [doi]
PST - epublish
SO  - J Vis Exp. 2014 Aug 5;(90):e51442. doi: 10.3791/51442.