PMID- 25146846
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20220409
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 52
IP  - 1
DP  - 2015 Aug
TI  - Lactoferrin Promotes Early Neurodevelopment and Cognition in Postnatal Piglets by 
      Upregulating the BDNF Signaling Pathway and Polysialylation.
PG  - 256-69
LID - 10.1007/s12035-014-8856-9 [doi]
AB  - Lactoferrin (Lf) is a sialic acid (Sia)-rich, iron-binding milk glycoprotein that 
      has multifunctional health benefits. Its potential role in neurodevelopment and 
      cognition remains unknown. To test the hypothesis that Lf may function to improve 
      neurodevelopment and cognition, the diet of postnatal piglets was supplemented 
      with Lf from days 3 to 38. Expression levels of selected genes and their cognate 
      protein profiles were quantitatively determined. The importance of our new 
      findings is that Lf (1) upregulated several canonical signaling pathways 
      associated with neurodevelopment and cognition; (2) influenced ~10 genes involved 
      in the brain-derived neurotrophin factor (BDNF) signaling pathway in the 
      hippocampus and upregulated the expression of polysialic acid, a marker of 
      neuroplasticity, cell migration and differentiation of progenitor cells, and the 
      growth and targeting of axons; (3) upregulated transcriptional and translational 
      levels of BDNF and increased phosphorylation of the cyclic adenosine 
      monophosphate (cAMP) response element-binding protein, CREB, a downstream target 
      of the BDNF signaling pathway, and a protein of crucial importance in 
      neurodevelopment and cognition; and (4) enhanced the cognitive function and 
      learning of piglets when tested in an eight-arm radial maze. The finding that Lf 
      can improve neural development and cognition in postnatal piglets has not been 
      previously described.
FAU - Chen, Yue
AU  - Chen Y
AD  - School of Medicine, Xiamen University, 361005, Xiamen, China.
FAU - Zheng, Zhiqiang
AU  - Zheng Z
FAU - Zhu, Xi
AU  - Zhu X
FAU - Shi, Yujie
AU  - Shi Y
FAU - Tian, Dandan
AU  - Tian D
FAU - Zhao, Fengjuan
AU  - Zhao F
FAU - Liu, Ni
AU  - Liu N
FAU - Huppi, Petra S
AU  - Huppi PS
FAU - Troy, Frederic A 2nd
AU  - Troy FA 2nd
FAU - Wang, Bing
AU  - Wang B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140823
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - EC 3.4.21.- (Lactoferrin)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cattle
MH  - Cognition/*drug effects
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Hippocampus/metabolism
MH  - Hydrocortisone/blood
MH  - Lactoferrin/*pharmacology
MH  - Male
MH  - Memory/drug effects
MH  - N-Acetylneuraminic Acid/*metabolism
MH  - Nerve Growth Factors/metabolism
MH  - Nervous System/drug effects/*growth & development
MH  - Neuronal Plasticity/drug effects
MH  - Oligonucleotide Array Sequence Analysis
MH  - Signal Transduction/*drug effects/genetics
MH  - Sus scrofa
MH  - Transcription, Genetic/drug effects
MH  - Up-Regulation/*drug effects
PMC - PMC4510916
COIS- YJ SHI is an employee of NRC Beijing. The authors declare that they have no 
      conflict of interest.
EDAT- 2014/08/26 06:00
MHDA- 2016/05/03 06:00
PMCR- 2014/08/23
CRDT- 2014/08/23 06:00
PHST- 2014/06/12 00:00 [received]
PHST- 2014/08/06 00:00 [accepted]
PHST- 2014/08/23 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2014/08/23 00:00 [pmc-release]
AID - 10.1007/s12035-014-8856-9 [pii]
AID - 8856 [pii]
AID - 10.1007/s12035-014-8856-9 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015 Aug;52(1):256-69. doi: 10.1007/s12035-014-8856-9. Epub 2014 
      Aug 23.