PMID- 25148720
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20201209
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 33
IP  - 9-10
DP  - 2014 Sep-Oct
TI  - [Argatroban, a new antithrombotic treatment for heparin-induced thrombocytopenia 
      application in cardiac surgery and in intensive care].
PG  - 514-23
LID - S0750-7658(14)00240-8 [pii]
LID - 10.1016/j.annfar.2014.06.006 [doi]
AB  - OBJECTIVES: Although heparin-induced thrombocytopemia (HIT) is uncommon, its 
      thromboembolic complications are potentially life-threatening. The low-molecular 
      weight heparins are less responsible of HIT than unfractionated heparin (UFH) but 
      this latter is still indicated in some circumstances such as cardiac surgery. 
      Argatroban, a selective thrombin inhibitor, recently available, has been 
      indicated in HIT treatment. This review presents the main pharmacological 
      characteristics, its indications and uses in the context of cardiac surgery and 
      in intensive care medicine. METHODS: Review of the literature in Medline database 
      over the past 15 years using the following keywords: argatroban, cardiac surgery, 
      circulatory assistance, cardiopulmonary bypass. RESULTS: Despite its short-acting 
      pharmacokinetic, argatroban cannot be recommended during cardiopulmonary bypass. 
      On the contrary, argatroban is indicated in many circumstances in postoperative 
      period of various cardiac surgeries (on-pump, off-pump, circulatory assistance). 
      Nevertheless, after cardiac surgery, doses have to be adapted according to 
      coagulation laboratory testing (ACT), particularly in patients presenting acute 
      organ failure (kidney injury, heart failure, liver failure). This compound has no 
      antagonist and is excluded during severe hepatic failure. The continuous 
      intravenous administration is a drawback. CONCLUSION: Argatroban is a new direct 
      competitive thrombin inhibitor well evaluated as treatment of HIT after cardiac 
      surgery. In HIT management, argatroban is an interesting alternative to lepirudin 
      that is not anymore available and danaparoid because of supply disturbances.
CI  - Copyright (c) 2014. Published by Elsevier SAS.
FAU - Rozec, B
AU  - Rozec B
AD  - Service d'anesthesie et de reanimation chirurgicale, hopital G-et-R-Laennec, CHU 
      de Nantes, boulevard Jacques-Monod, 44093 Nantes cedex 1, France. Electronic 
      address: bertrand.rozec@chu-nantes.fr.
FAU - Boissier, E
AU  - Boissier E
AD  - Laboratoire d'hematologie, CHU de Nantes, 44093 Nantes cedex 1, France.
FAU - Godier, A
AU  - Godier A
AD  - Service d'anesthesie et de reanimation chirurgicale, groupe hospitalier 
      Cochin-Hotel-Dieu, Assistance publique-Hopitaux de Paris, 27, rue du 
      Faubourg-Saint-Jacques, 75014 Paris, France.
FAU - Cinotti, R
AU  - Cinotti R
AD  - Service d'anesthesie et de reanimation chirurgicale, hopital G-et-R-Laennec, CHU 
      de Nantes, boulevard Jacques-Monod, 44093 Nantes cedex 1, France.
FAU - Stephan, F
AU  - Stephan F
AD  - Reanimation adultes, centre chirurgicale Marie-Lannelongue, 92350 Le 
      Plessis-Robinson, France.
FAU - Blanloeil, Y
AU  - Blanloeil Y
AD  - Service d'anesthesie et de reanimation chirurgicale, hopital G-et-R-Laennec, CHU 
      de Nantes, boulevard Jacques-Monod, 44093 Nantes cedex 1, France.
LA  - fre
PT  - Journal Article
PT  - Review
TT  - L'argatroban, nouvel antithrombotique pour la thrombopenie induite par l'heparine 
      en chirurgie cardiaque de l'adulte: utilisation en chirurgie cardiaque et en 
      reanimation.
DEP - 20140820
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 0 (Anticoagulants)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Pipecolic Acids)
RN  - 0 (Sulfonamides)
RN  - 9005-49-6 (Heparin)
RN  - 94ZLA3W45F (Arginine)
RN  - IY90U61Z3S (argatroban)
SB  - IM
MH  - Anticoagulants/*adverse effects
MH  - Arginine/analogs & derivatives
MH  - Cardiac Surgical Procedures/*methods
MH  - Critical Care/*methods
MH  - Fibrinolytic Agents/pharmacokinetics/pharmacology/*therapeutic use
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Pipecolic Acids/pharmacokinetics/pharmacology/*therapeutic use
MH  - Sulfonamides
MH  - Thrombocytopenia/*chemically induced/*drug therapy
OTO - NOTNLM
OT  - Argatroban
OT  - Assistance circulatoire
OT  - Cardiac surgery
OT  - Chirurgie cardiaque
OT  - Circulatory assistance
OT  - Heparin-induced thrombocytopenia
OT  - Thrombopenie induite par l'heparine
EDAT- 2014/08/26 06:00
MHDA- 2015/07/28 06:00
CRDT- 2014/08/24 06:00
PHST- 2013/08/21 00:00 [received]
PHST- 2014/06/27 00:00 [accepted]
PHST- 2014/08/24 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
AID - S0750-7658(14)00240-8 [pii]
AID - 10.1016/j.annfar.2014.06.006 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2014 Sep-Oct;33(9-10):514-23. doi: 
      10.1016/j.annfar.2014.06.006. Epub 2014 Aug 20.