PMID- 25148799
OWN - NLM
STAT- MEDLINE
DCOM- 20150720
LR  - 20191210
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 13
IP  - 6
DP  - 2014 Dec
TI  - Interleukin-25 Enhances Allergic Inflammation through p38MAPK and NF-kappaB Pathways 
      in Mouse Models of Allergic Rhinitis.
PG  - 412-9
AB  - Interleukin (IL)-25, a cytokine of IL-17 family, can activate p38 
      Mitogen-Activated Protein kinases(MAPK) and Nuclear Factor(NF)-kappaB pathways to 
      propagate Th2 responses. The allergic rhinitis mouse model was established by 
      stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of 
      IL-25 and downstream p38MAPK and NF-kappaB. The expression of IL-25, p38MAPK and 
      NF-kappaB were detected in the OVA-induced allergic rhinitis mouse model. The 
      allergic parameters, such as allergic symptoms, serum OVA-specific immunoglobulin 
      E (IgE) levels and eosinophil infiltration in the nasal mucosa were compared 
      between OVA group and control group. OVA-induced mice displayed significantly 
      higher allergic responses compared with the saline control group. OVA induced 
      mice demonstrated more allergic symptoms, higher serum OVA-specific IgE levels 
      and eosinophil infiltrations. The increased expression of IL-25, p38MAPK and 
      NF-kappaB immunoreactivity were detected in epidermal cells in the OVA group. The 
      mRNA measurement of IL-25, p38MAPK and NF-kappaB showed the same result. IL-25 
      enhances the OVA-induced allergic rhinitis by activating p38MAPK and NF-kappaB 
      pathways.
FAU - Li, Zhipeng
AU  - Li Z
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China. 
      lizhipeng-rose@hotmail.com.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China. 
      317411734@qq.com.
FAU - Liu, Lisi
AU  - Liu L
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China. 
      liulisient@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Interleukins)
RN  - 0 (Mydgf protein, mouse)
RN  - 0 (NF-kappa B)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Interleukins/analysis/genetics/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/analysis/genetics/*physiology
MH  - Ovalbumin/immunology
MH  - Rhinitis, Allergic/*etiology
MH  - Signal Transduction/*physiology
MH  - p38 Mitogen-Activated Protein Kinases/analysis/genetics/*physiology
EDAT- 2014/08/26 06:00
MHDA- 2015/07/21 06:00
CRDT- 2014/08/24 06:00
PHST- 2013/11/13 00:00 [received]
PHST- 2014/04/08 00:00 [accepted]
PHST- 2014/02/26 00:00 [revised]
PHST- 2014/08/24 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/07/21 06:00 [medline]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2014 Dec;13(6):412-9.