PMID- 25148887
OWN - NLM
STAT- MEDLINE
DCOM- 20151014
LR  - 20221207
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 25
IP  - 3
DP  - 2015 Mar
TI  - Epicardial and pericardial fat in type 2 diabetes: favourable effects of 
      biliopancreatic diversion.
PG  - 477-85
LID - 10.1007/s11695-014-1400-1 [doi]
AB  - PURPOSE: Ectopic fat is often identified in obese subjects who are susceptible to 
      the development of type 2 diabetes mellitus (T2DM). The ectopic fat favours the 
      decrease in insulin sensitivity (IS) and adiponectin levels. We aimed to evaluate 
      the effect of biliopancreatic diversion (BPD) on the accumulation of ectopic fat, 
      adiponectin levels and IS in obese with T2DM. MATERIALS AND METHODS: A 
      nonrandomised controlled study was performed on sixty-eight women: 19 
      lean-control (23.0 +/- 2.2 kg/m(2)) and 18 obese-control (35.0 +/- 4.8 kg/m(2)) with 
      normal glucose tolerance and 31 obese with T2DM (36.3 +/- 3.7 kg/m(2)). Of the 31 
      diabetic women, 20 underwent BPD and were reassessed 1 month and 12 months after 
      surgery. The subcutaneous adipose tissue, visceral adipose tissue, epicardial 
      adipose tissue and pericardial adipose tissue were evaluated by ultrasonography. 
      The IS was assessed by a hyperglycaemic clamp, applying the minimal model of 
      glucose. RESULTS: One month after surgery, there was a reduction in visceral and 
      subcutaneous adipose tissues, whereas epicardial and pericardial adipose tissues 
      exhibited significant reduction at the 12-month assessment (p < 0.01). 
      Adiponectin levels and IS were normalised 1 month after surgery, resembling 
      lean-control values and elevated above the obese-control values (p < 0.01). After 
      12 months, the improvement in IS and adiponectin was maintained, and 17 of the 20 
      operated patients exhibited fasting glucose and glycated haemoglobin within the 
      normal range. CONCLUSIONS: After BPD, positive physiological adaptations occurred 
      in grade I and II obese patients with T2DM. These adaptations relate to the 
      restoration of IS and decreased adiposopathy and explain the acute (1 month) and 
      chronic (12 months) improvements in the glycaemic control.
FAU - Vasques, Ana Carolina Junqueira
AU  - Vasques AC
AD  - School of Applied Sciences (FCA), State University of Campinas, UNICAMP, Limeira, 
      Sao Paulo, Brazil, ana.vasques@fca.unicamp.br.
FAU - Pareja, Jose Carlos
AU  - Pareja JC
FAU - Souza, Jose Roberto Mattos
AU  - Souza JR
FAU - Yamanaka, Ademar
AU  - Yamanaka A
FAU - de Oliveira, Maria da Saude
AU  - de Oliveira Mda S
FAU - Novaes, Fernanda Satake
AU  - Novaes FS
FAU - Chaim, Elinton Adami
AU  - Chaim EA
FAU - Piccinini, Francesca
AU  - Piccinini F
FAU - Dalla Man, Chiara
AU  - Dalla Man C
FAU - Cobelli, Claudio
AU  - Cobelli C
FAU - Geloneze, Bruno
AU  - Geloneze B
LA  - eng
SI  - ReBec/RBR-9KDZDV
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adipose Tissue/*diagnostic imaging/pathology
MH  - Adiposity
MH  - Adult
MH  - *Biliopancreatic Diversion
MH  - Diabetes Mellitus, Type 2/complications/*diagnostic imaging/metabolism/*surgery
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hyperglycemia/complications/diagnostic imaging/metabolism/surgery
MH  - Insulin Resistance/physiology
MH  - Intra-Abdominal Fat/diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*diagnostic imaging/metabolism/*surgery
MH  - Pericardium/*diagnostic imaging/pathology
MH  - Subcutaneous Fat/diagnostic imaging/physiopathology
MH  - Ultrasonography
EDAT- 2014/08/26 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/08/24 06:00
PHST- 2014/08/24 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.1007/s11695-014-1400-1 [doi]
PST - ppublish
SO  - Obes Surg. 2015 Mar;25(3):477-85. doi: 10.1007/s11695-014-1400-1.