PMID- 25149074
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20220330
IS  - 1674-8018 (Electronic)
IS  - 1674-800X (Print)
IS  - 1674-800X (Linking)
VI  - 5
IP  - 11
DP  - 2014 Nov
TI  - MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating 
      AMFR and NOTCH1.
PG  - 851-61
LID - 10.1007/s13238-014-0093-5 [doi]
AB  - MicroRNAs (miRNAs) that exert function by posttranscriptional suppression have 
      recently brought insight in our understanding of the role of non-protein-coding 
      RNAs in carcinogenesis and metastasis. In this study, we described the function 
      and molecular mechanism of miR-139-5p in colorectal cancer (CRC) and its 
      potential clinical application in CRC. We found that miR-139-5p was significantly 
      downregulated in 73.8% CRC samples compared with adjacent noncancerous tissues 
      (NCTs), and decreased miR-139-5p was associated with poor prognosis. Functional 
      analyses demonstrated that ectopic expression of miR-139-5p suppressed CRC cell 
      migration and invasion in vitro and metastasis in vivo. Mechanistic 
      investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis 
      by targeting AMFR and NOTCH1. Knockdown of the two genes phenocopied the 
      inhibitory effect of miR-139-5p on CRC metastasis. Furthermore, the protein 
      levels of the two genes were upregulated in CRC samples compared with NCTs, and 
      inversely correlated with the miR-139-5p expression. Increased NOTCH1 protein 
      expression was correlated with poor prognosis of CRC patients. Together, our data 
      indicate that miR-139-5p is a potential tumor suppressor and prognostic factor 
      for CRC, and targeting miR-139-5p may repress the metastasis of CRC and improve 
      survival.
FAU - Song, Mingxu
AU  - Song M
AD  - Wuxi Oncology Institute, the Affiliated Hospital of Jiangnan University, Wuxi, 
      214062, China.
FAU - Yin, Yuan
AU  - Yin Y
FAU - Zhang, Jiwei
AU  - Zhang J
FAU - Zhang, Binbin
AU  - Zhang B
FAU - Bian, Zehua
AU  - Bian Z
FAU - Quan, Chao
AU  - Quan C
FAU - Zhou, Leyuan
AU  - Zhou L
FAU - Hu, Yaling
AU  - Hu Y
FAU - Wang, Qifeng
AU  - Wang Q
FAU - Ni, Shujuan
AU  - Ni S
FAU - Fei, Bojian
AU  - Fei B
FAU - Wang, Weili
AU  - Wang W
FAU - Du, Xiang
AU  - Du X
FAU - Hua, Dong
AU  - Hua D
FAU - Huang, Zhaohui
AU  - Huang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140823
PL  - Germany
TA  - Protein Cell
JT  - Protein & cell
JID - 101532368
RN  - 0 (MIRN139 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (NOTCH1 protein, human)
RN  - 0 (Receptor, Notch1)
RN  - EC 2.3.2.27 (AMFR protein, human)
RN  - EC 2.3.2.27 (Receptors, Autocrine Motility Factor)
SB  - IM
EIN - Protein Cell. 2021 Aug;12(8):668-670. PMID: 33559815
MH  - Animals
MH  - Base Sequence
MH  - Cell Line, Tumor
MH  - Cell Movement/*genetics
MH  - Colorectal Neoplasms/*genetics/pathology/therapy
MH  - *Down-Regulation
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - HCT116 Cells
MH  - HEK293 Cells
MH  - Humans
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - RNA Interference
MH  - Receptor, Notch1/*genetics/metabolism
MH  - Receptors, Autocrine Motility Factor/*genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Nucleic Acid
MH  - Survival Analysis
MH  - Xenograft Model Antitumor Assays
PMC - PMC4225484
EDAT- 2014/08/26 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/08/23
CRDT- 2014/08/24 06:00
PHST- 2014/06/14 00:00 [received]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/08/24 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/08/23 00:00 [pmc-release]
AID - 93 [pii]
AID - 10.1007/s13238-014-0093-5 [doi]
PST - ppublish
SO  - Protein Cell. 2014 Nov;5(11):851-61. doi: 10.1007/s13238-014-0093-5. Epub 2014 
      Aug 23.