PMID- 25150532
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20141202
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 59
IP  - 12
DP  - 2014 Dec
TI  - Impaired mastication reduced newly generated neurons at the accessory olfactory 
      bulb and pheromonal responses in mice.
PG  - 1272-8
LID - S0003-9969(14)00203-9 [pii]
LID - 10.1016/j.archoralbio.2014.07.018 [doi]
AB  - OBJECTIVES: A large number of neurons are generated at the subventricular zone 
      (SVZ) even during adulthood. In a previous study, we have shown that a reduced 
      mastication impairs both neurogenesis in the SVZ and olfactory functions. 
      Pheromonal signals, which are received by the vomeronasal organ, provide 
      information about reproductive and social states. Vomeronasal sensory neurons 
      project to the accessory olfactory bulb (AOB) located on the dorso-caudal surface 
      of the main olfactory bulb. Newly generated neurons at the SVZ migrate to the AOB 
      and differentiate into granule cells and periglomerular cells. This study aimed 
      to explore the effects of changes in mastication on newly generated neurons and 
      pheromonal responses. DESIGN: Bromodeoxyuridine-immunoreactive (BrdU-ir; a marker 
      of DNA synthesis) and Fos-ir (a marker of neurons excited) structures in sagittal 
      sections of the AOB after exposure to urinary odours were compared between the 
      mice fed soft and hard diets. RESULTS: The density of BrdU-ir cells in the AOB in 
      the soft-diet-fed mice after 1 month was essentially similar to that of the 
      hard-diet-fed mice, while that was lower in the soft-diet-fed mice for 3 or 6 
      months than in the hard-diet-fed mice. The density of Fos-ir cells in the 
      soft-diet-fed mice after 2 months was essentially similar to that in the 
      hard-diet-fed mice, while that was lower in the soft-diet-fed mice for 4 months 
      than in the hard-diet-fed mice. CONCLUSIONS: The present results suggest that 
      impaired mastication reduces newly generated neurons at the AOB, which in turn 
      impairs olfactory function at the AOB.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Utsugi, Chizuru
AU  - Utsugi C
AD  - Department of Oral and Maxillofacial Surgery, Asahikawa Medical University, 
      Asahikawa 078-8510, Japan; Department of Sensory Physiology, Asahikawa Medical 
      University, Asahikawa 078-8510, Japan.
FAU - Miyazono, Sadaharu
AU  - Miyazono S
AD  - Department of Sensory Physiology, Asahikawa Medical University, Asahikawa 
      078-8510, Japan.
FAU - Osada, Kazumi
AU  - Osada K
AD  - Department of Oral Biology, School of Dentistry, Health Sciences University of 
      Hokkaido, Tohbetu 061-0293, Japan.
FAU - Matsuda, Mitsuyoshi
AU  - Matsuda M
AD  - Department of Oral and Maxillofacial Surgery, Asahikawa Medical University, 
      Asahikawa 078-8510, Japan.
FAU - Kashiwayanagi, Makoto
AU  - Kashiwayanagi M
AD  - Department of Sensory Physiology, Asahikawa Medical University, Asahikawa 
      078-8510, Japan. Electronic address: yanagi@asahikawa-med.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140802
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Bromodeoxyuridine
MH  - *Diet
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Mastication/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurogenesis/*physiology
MH  - Olfactory Bulb/*cytology/physiology
MH  - Pheromones/urine
MH  - Proto-Oncogene Proteins c-fos
MH  - Smell/*physiology
MH  - Time Factors
OTO - NOTNLM
OT  - Hard diet
OT  - Mastication
OT  - Olfactory function
OT  - Pheromone
OT  - Soft diet
EDAT- 2014/08/26 06:00
MHDA- 2015/08/04 06:00
CRDT- 2014/08/25 06:00
PHST- 2014/04/30 00:00 [received]
PHST- 2014/07/22 00:00 [accepted]
PHST- 2014/08/25 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
AID - S0003-9969(14)00203-9 [pii]
AID - 10.1016/j.archoralbio.2014.07.018 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2014 Dec;59(12):1272-8. doi: 10.1016/j.archoralbio.2014.07.018. 
      Epub 2014 Aug 2.