PMID- 25150586 OWN - NLM STAT- MEDLINE DCOM- 20161006 LR - 20211021 IS - 1615-2573 (Electronic) IS - 0910-8327 (Linking) VI - 31 IP - 1 DP - 2016 Jan TI - High serum levels of thrombospondin-2 correlate with poor prognosis of patients with heart failure with preserved ejection fraction. PG - 52-9 LID - 10.1007/s00380-014-0571-y [doi] AB - Thrombospondin-2 (TSP-2) is highly expressed in hypertensive heart. Interstitial fibrosis is frequently observed in hypertensive heart, and it is a characteristic feature of heart failure with preserved ejection fraction (HFpEF). We tested here the hypothesis that high TSP-2 serum levels reflect disease severity and can predict poor prognosis of patients with HFpEF. Serum TSP-2 levels were measured by ELISA in 150 patients with HFpEF. HFpEF was defined as left ventricular ejection fraction >/= 50%, B-type natriuretic peptide (BNP) >/= 100 pg/ml or E/e' >/= 15. The endpoints were mortality rate, HF-related hospitalization, stroke and non-fatal myocardial infarction. The median serum TSP-2 level was 19.2 (14.4-26.0) ng/ml. Serum TSP-2 levels were associated with the New York Heart Association (NYHA) functional class. Circulating levels of BNP and high-sensitivity troponin T were positively correlated with serum TSP-2 levels. Kaplan-Meier survival curve showed high risk of adverse cardiovascular events in the high TSP-2 group (>median value), and that the combination of high TSP-2 and high BNP (>/= 100 pg/ml) was associated with the worst event-free survival rate. Multivariate Cox proportional hazard analysis identified TSP-2 as independent predictor of risk of death and cardiovascular events. Circulating TSP-2 correlates with disease severity in patients with HFpEF. TSP-2 is a potentially useful predictor of future adverse cardiovascular events in patients with HFpEF. FAU - Kimura, Yuichi AU - Kimura Y AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Izumiya, Yasuhiro AU - Izumiya Y AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. izumiya@kumamoto-u.ac.jp. FAU - Hanatani, Shinsuke AU - Hanatani S AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Yamamoto, Eiichiro AU - Yamamoto E AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Kusaka, Hiroaki AU - Kusaka H AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Tokitsu, Takanori AU - Tokitsu T AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Takashio, Seiji AU - Takashio S AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Sakamoto, Kenji AU - Sakamoto K AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Tsujita, Kenichi AU - Tsujita K AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Tanaka, Tomoko AU - Tanaka T AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Yamamuro, Megumi AU - Yamamuro M AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Kojima, Sunao AU - Kojima S AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Tayama, Shinji AU - Tayama S AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Kaikita, Koichi AU - Kaikita K AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Hokimoto, Seiji AU - Hokimoto S AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. FAU - Ogawa, Hisao AU - Ogawa H AD - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140824 PL - Japan TA - Heart Vessels JT - Heart and vessels JID - 8511258 RN - 0 (Biomarkers) RN - 0 (Thrombospondins) RN - 0 (thrombospondin 2) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Aged MH - Aged, 80 and over MH - Biomarkers/blood MH - Disease-Free Survival MH - Female MH - Heart Failure/*physiopathology MH - Humans MH - Japan MH - Kaplan-Meier Estimate MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/*blood MH - Prognosis MH - Severity of Illness Index MH - *Stroke Volume MH - Thrombospondins/*blood MH - Ventricular Function, Left OTO - NOTNLM OT - Biomarker OT - HFpEF OT - Prognosis OT - Thrombospondin-2 EDAT- 2014/08/26 06:00 MHDA- 2016/10/08 06:00 CRDT- 2014/08/25 06:00 PHST- 2014/05/01 00:00 [received] PHST- 2014/08/15 00:00 [accepted] PHST- 2014/08/25 06:00 [entrez] PHST- 2014/08/26 06:00 [pubmed] PHST- 2016/10/08 06:00 [medline] AID - 10.1007/s00380-014-0571-y [pii] AID - 10.1007/s00380-014-0571-y [doi] PST - ppublish SO - Heart Vessels. 2016 Jan;31(1):52-9. doi: 10.1007/s00380-014-0571-y. Epub 2014 Aug 24.