PMID- 25151210
OWN - NLM
STAT- MEDLINE
DCOM- 20150825
LR  - 20151119
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 20
IP  - 11
DP  - 2014 Nov
TI  - Prognostic impact of combined late gadolinium enhancement on cardiovascular 
      magnetic resonance and peak oxygen consumption in ambulatory patients with 
      nonischemic dilated cardiomyopathy.
PG  - 825-32
LID - S1071-9164(14)01130-0 [pii]
LID - 10.1016/j.cardfail.2014.08.005 [doi]
AB  - BACKGROUND: Peak oxygen consumption (peak VO(2)) and late gadolinium enhancement 
      (LGE) on cardiovascular magnetic resonance (CMR) are prognostic in heart failure. 
      We investigated whether LGE-CMR and peak VO(2)combined had additive value in risk 
      stratifying patients with nonischemic dilated cardiomyopathy (DCM). METHODS AND 
      RESULTS: Fifty-seven DCM patients underwent CMR and cardiopulmonary exercise 
      testing. Cardiac events were cardiac death, hospitalization for decompensated 
      heart failure, or lethal arrhythmia. Twenty-five (44%) were LGE-positive. The 
      median peak VO(2)was 18.5 mL.kg(-1).min(-1). On multivariate analysis, positive LGE 
      (P = .048) and peak VO(2)(P = .003) were independent cardiac event predictors. 
      Cardiac event risk was significantly higher with positive LGE and peak VO(2)< 18.5 
      mL .kg(-)(1) .min(-)(1) than with negative LGE and peak VO(2)>/= 18.5 mL . kg(-)(1) . min(-)(1) 
      (hazard ratio 12.5; 95% CI 1.57-100; P = .017). In 3 patient groups (group A: no 
      LGE, peak VO(2)>/= 18.5 mL . kg(-)(1) . min(-)(1), n = 18; group B: positive LGE or peak VO(2)< 
      18.5 mL . kg(-)(1) . min(-)(1), n = 24; group C: positive LGE and peak VO(2)< 18.5 mL . 
      kg(-)(1) . min(-)(1), n = 15) during follow-up (71 +/- 32 months), group C had higher 
      cardiac event rates than the others. CONCLUSIONS: Combined assessment of LGE-CMR 
      and peak VO(2)provides additive prognostic information in ambulatory DCM.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Yamada, Takashi
AU  - Yamada T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Hirashiki, Akihiro
AU  - Hirashiki A
AD  - Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University 
      Graduate School of Medicine, Nagoya, Japan. Electronic address: 
      hirasiki@med.nagoya-u.ac.jp.
FAU - Okumura, Takahiro
AU  - Okumura T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Adachi, Shiro
AU  - Adachi S
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Shimazu, Shuzo
AU  - Shimazu S
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Shimizu, Shinya
AU  - Shimizu S
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Morimoto, Ryota
AU  - Morimoto R
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Takeshita, Kyosuke
AU  - Takeshita K
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Naganawa, Shinji
AU  - Naganawa S
AD  - Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Kondo, Takahisa
AU  - Kondo T
AD  - Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University 
      Graduate School of Medicine, Nagoya, Japan.
FAU - Murohara, Toyoaki
AU  - Murohara T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20140821
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Cardiomyopathy, Dilated/*diagnosis/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - *Gadolinium
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/metabolism/pathology
MH  - *Outpatients
MH  - Oxygen Consumption/*physiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Time Factors
OTO - NOTNLM
OT  - Exercise tolerance
OT  - magnetic resonance imaging
OT  - prognosis
EDAT- 2014/08/26 06:00
MHDA- 2015/08/26 06:00
CRDT- 2014/08/25 06:00
PHST- 2014/02/22 00:00 [received]
PHST- 2014/06/20 00:00 [revised]
PHST- 2014/08/14 00:00 [accepted]
PHST- 2014/08/25 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/08/26 06:00 [medline]
AID - S1071-9164(14)01130-0 [pii]
AID - 10.1016/j.cardfail.2014.08.005 [doi]
PST - ppublish
SO  - J Card Fail. 2014 Nov;20(11):825-32. doi: 10.1016/j.cardfail.2014.08.005. Epub 
      2014 Aug 21.