PMID- 25152111
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20140825
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 35
IP  - 8
DP  - 2014 Aug
TI  - [The impact of HLA matching on outcome of single unit unrelated cord blood 
      transplantation: a retrospective single center clinical analysis].
PG  - 678-83
LID - 10.3760/cma.j.issn.0253-2727.2014.08.002 [doi]
AB  - OBJECTIVE: To retrospectively study the impact of human leukocyte antigen (HLA) 
      mtyping mismatching between donor and recipient on outcome of single unit 
      unrelated cord blood transplantation (sUCBT). METHODS: 139 patients with 
      hematological malignancies received sUCBT in single center from May 2008 to 
      August 2012 were analyzed. Of 139 patients at enrollment, 22 were 0 mismatched 
      (mm), 69 1 mm, 48 2 mm by low-resolution HLA-A, -B, and high-resolution (HR) 
      DRB1. All patients'conditioning regimen was myeloablative, and a combination of 
      cyclosporine A (CsA) and mycophenolate mofetil (MMF) was given for 
      graft-versus-host disease (GVHD) prophylaxis for all patients. The cohort of 
      patients were followed-up until December 15, 2013. RESULTS: Patients of 0 mm had 
      a statistically significant higher cumulative incidence of neutrophil engraftment 
      by day 42 than those of 1 and 2 mm (P=0.042 and 0.002, respectively), patients of 
      0 mm with either a higher prefreeze total nucleated cell (TNC) dose (>5 x 10(7)/kg) 
      or lower dose (<5 x 10(7)/kg) had a statistically significant higher cumulative 
      incidence of neutrophil engraftment by day 42 than those of 2 mm (P=0.01 and 
      0.02, respectively). Patients of 0 mm had a statistically significant lower 
      cumulative incidence of acute GVHD by day 100 than those of 1 and 2 mm (P=0.006 
      and 0.001, respectively). The difference of 1-year transplant-related mortality 
      (TRM) between 0 and 2 mm patients was statistically significant (P=0.03). 
      Patients of 2 mm received UCB units with a TNC dose less than 5 x 10(7)/kg had a 
      higher 1-year TRM than of 0 mm patients (P=0.03). Patients of 0 mm had a 
      statistically significant higher 3-year disease free survival (DFS) than those of 
      2 mm (P=0.03), compared with patients of 2 mm given CB units with a TNC dose less 
      than 5 x 10(7)/kg, 0 mm patients and 1mm patients received UCB units with a TNC 
      dose greater than 4 x 10(7)/kg had higher DFS rates (P=0.02 and 0.02, 
      respectively). CONCLUSION: The HLA typing mismatching between donor and recipient 
      had a great impact on neutrophil engraftment and long term DFS after sUCBT, 2mm 
      cord blood unit with less TNC (<5 x 10(7)/kg) was not an optimum UCB graft.
FAU - Sun, Guangyu
AU  - Sun G
AD  - Department of Hematology, Affiliated Provincial Hospital, Anhui Medical 
      University, Hefei 230001, China.
FAU - Sun, Zimin
AU  - Sun Z
AD  - Department of Hematology, Affiliated Provincial Hospital, Anhui Medical 
      University, Hefei 230001, China.
FAU - Liu, Huilan
AU  - Liu H
AD  - Department of Hematology, Affiliated Provincial Hospital, Anhui Medical 
      University, Hefei 230001, China.
FAU - Zheng, Changcheng
AU  - Zheng C
AD  - Department of Hematology, Affiliated Provincial Hospital, Anhui Medical 
      University, Hefei 230001, China.
FAU - Tang, Baolin
AU  - Tang B
AD  - Department of Hematology, Affiliated Provincial Hospital, Anhui Medical 
      University, Hefei 230001, China.
FAU - Zhu, Xiaoyu
AU  - Zhu X
AD  - Department of Hematology, Affiliated Provincial Hospital, Anhui Medical 
      University, Hefei 230001, China.
FAU - Song, Kaidi
AU  - Song K
AD  - Department of Hematology, Affiliated Provincial Hospital, Anhui Medical 
      University, Hefei 230001, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - *Cord Blood Stem Cell Transplantation
MH  - Female
MH  - Follow-Up Studies
MH  - HLA Antigens/*immunology
MH  - Hematologic Neoplasms/*therapy
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2014/08/26 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/08/26 06:00
PHST- 2014/08/26 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.3760/cma.j.issn.0253-2727.2014.08.002 [doi]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2014 Aug;35(8):678-83. doi: 
      10.3760/cma.j.issn.0253-2727.2014.08.002.