PMID- 25152240
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20211021
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 39
IP  - 1
DP  - 2015 Jan
TI  - Grape seed procyanidin supplementation to rats fed a high-fat diet during 
      pregnancy and lactation increases the body fat content and modulates the 
      inflammatory response and the adipose tissue metabolism of the male offspring in 
      youth.
PG  - 7-15
LID - 10.1038/ijo.2014.159 [doi]
AB  - OBJECTIVE: Procyanidins are polyphenolic bioactive compounds that exert 
      beneficial effects against obesity and its related diseases. The aim of this 
      study was to evaluate whether supplementation with low doses of a grape seed 
      procyanidin extract (GSPE) to rats during pre- and postnatal periods provides 
      biological effects to their offspring in youth. DESIGN: The metabolic programming 
      effect of GSPE was evaluated in the 30-day-old male offspring of four groups of 
      rats that were fed either a standard diet (STD) or a high-fat diet (HFD) and that 
      were supplemented with either GSPE (25 mg kg(-1) of body weight per day) or 
      vehicle during pregnancy and lactation. RESULTS: Significant increases in the 
      adiposity index and in the weights of all the white adipose tissue depots studied 
      (retroperitoneal, mesenteric, epididymal (EWAT) and inguinal) were observed in 
      the offspring of rats that were fed a HFD and that were treated with GSPE 
      (HFD-GSPE group) compared with the offspring of rats that were fed the same diet 
      but that did not receive the procyanidins (HFD group). The HFD-GSPE animals also 
      exhibited a higher number of cells in the EWAT, a sharp decrease in the 
      circulating levels of monocyte chemoattractant protein-1 (MCP-1) and a moderate 
      decrease in the plasma glycerol levels. The transcriptomic analysis performed in 
      the EWAT showed 238 genes that were differentially expressed between the HFD and 
      the HFD-GSPE animals, most of which were associated with the immune function and 
      the inflammatory response, in addition to genes associated with adipose tissue 
      remodeling and function, lipid and glucose homeostasis and the metabolism of 
      methyl groups. CONCLUSION: The GSPE treatment in rats that were fed an HFD during 
      pregnancy and lactation induced a clear metabolic programming effect in the 
      offspring, increasing adiposity, decreasing the circulating levels of MCP-1 and 
      changing the gene expression in the EWAT toward a better inflammatory profile.
FAU - del Bas, J M
AU  - del Bas JM
AD  - Nutrition and Health Research Group, Centre Tecnologic de Nutricio i Salut 
      (CTNS), TECNIO, CEICS, Reus, Spain.
FAU - Crescenti, A
AU  - Crescenti A
AD  - Nutrition and Health Research Group, Centre Tecnologic de Nutricio i Salut 
      (CTNS), TECNIO, CEICS, Reus, Spain.
FAU - Arola-Arnal, A
AU  - Arola-Arnal A
AD  - Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 
      Universitat Rovira i Virgili, Tarragona, Spain.
FAU - Oms-Oliu, G
AU  - Oms-Oliu G
AD  - Department of Food Technology, University of Lleida, Lleida, Spain.
FAU - Arola, L
AU  - Arola L
AD  - 1] Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, 
      Universitat Rovira i Virgili, Tarragona, Spain [2] Centre Tecnologic de Nutricio 
      i Salut (CTNS), TECNIO, CEICS, Reus, Spain.
FAU - Caimari, A
AU  - Caimari A
AD  - Nutrition and Health Research Group, Centre Tecnologic de Nutricio i Salut 
      (CTNS), TECNIO, CEICS, Reus, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140825
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Antioxidants)
RN  - 0 (Biflavonoids)
RN  - 0 (Grape Seed Extract)
RN  - 0 (Plant Extracts)
RN  - 0 (Proanthocyanidins)
RN  - 4852-22-6 (procyanidin)
RN  - 8R1V1STN48 (Catechin)
SB  - IM
MH  - Adipose Tissue/*drug effects/immunology
MH  - Animals
MH  - Animals, Newborn
MH  - Antioxidants/*pharmacology
MH  - Biflavonoids/*pharmacology
MH  - Body Weight
MH  - Catechin/*pharmacology
MH  - Diet, High-Fat
MH  - Female
MH  - Grape Seed Extract/*pharmacology
MH  - Inflammation/*prevention & control
MH  - Lactation/*drug effects/immunology
MH  - Lipid Metabolism
MH  - Male
MH  - Plant Extracts/pharmacology
MH  - Pregnancy
MH  - Proanthocyanidins/*pharmacology
MH  - Rats
EDAT- 2014/08/26 06:00
MHDA- 2015/09/15 06:00
CRDT- 2014/08/26 06:00
PHST- 2014/04/24 00:00 [received]
PHST- 2014/07/22 00:00 [revised]
PHST- 2014/08/13 00:00 [accepted]
PHST- 2014/08/26 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - ijo2014159 [pii]
AID - 10.1038/ijo.2014.159 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2015 Jan;39(1):7-15. doi: 10.1038/ijo.2014.159. Epub 2014 Aug 
      25.