PMID- 25152298
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20141202
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 156
DP  - 2014 Oct 28
TI  - Antidepressant-like effect of Butea superba in mice exposed to chronic mild 
      stress and its possible mechanism of action.
PG  - 16-25
LID - S0378-8741(14)00608-4 [pii]
LID - 10.1016/j.jep.2014.08.014 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Butea superba (BS) is a Thai medicinal plant that 
      has been used as a folk medicine to improve physical and mental conditions and to 
      prevent impaired sexual performance in middle-aged or elderly males. We have 
      previously reported that this plant extract could improve cognitive deficits and 
      depression-like behavior in olfactory bulbectomized mice, an animal model of 
      dementia and depression. AIM OF THE STUDY: In this study we examined the effect 
      of BS on depression-like behavior in mice subjected to unpredictable chronic mild 
      stress (UCMS) to clarify the antidepressant-like activity of BS and the molecular 
      mechanism underlying this effect. MATERIALS AND METHODS: UCMS mice were 
      administered BS daily (300 mg of dried herb weight/kg, p.o.) or a reference drug, 
      imipramine (IMP, 10 mg/kg, i.p.), 1 week after starting the UCMS procedure. We 
      employed the sucrose preference test and the tail suspension test to analyze 
      anhedonia and depression-like behavior of mice, respectively. Serum and brain 
      tissues of mice were used for neurochemical and immunohistochemical studies. The 
      UCMS procedure induced anhedonia and depression-like behavior, and BS treatment, 
      as well as IMP treatment, attenuated these symptoms. UCMS caused an elevation of 
      serum corticosterone level, an index of hyper-activation of the 
      hypothalamic-pituitary-adrenal (HPA) axis, in a manner attenuated by BS and IMP 
      treatment. BS treatment also attenuated UCMS-induced decrease in the expression 
      levels of brain-derived neurotrophic factor (BDNF) mRNA, cyclic AMP-responsive 
      element binding protein (CREB) and a phosphorylated form of N-methyl-d-aspartate 
      receptor subunit NR1, synaptic plasticity-related signaling proteins. Moreover, 
      the UCMS procedure reduced doublecortin-positive cells in the dentate gyrus 
      region of the hippocampus. BS administration reversed these UCMS-induced 
      neurochemical and histological abnormalities. CONCLUSION: These results suggest 
      that BS can ameliorate chronic stress-induced depression-like symptoms and that 
      the effects of BS are mediated by restoring dysfunctions of the HPA axis and 
      synaptic plasticity-related signaling systems and neurogenesis in the 
      hippocampus.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Mizuki, Daishu
AU  - Mizuki D
AD  - Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, 
      Toyama 930-0194, Japan.
FAU - Matsumoto, Kinzo
AU  - Matsumoto K
AD  - Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, 
      Toyama 930-0194, Japan. Electronic address: mkinzo@inm.u-toyama.ac.jp.
FAU - Tanaka, Ken
AU  - Tanaka K
AD  - Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, 
      Toyama 930-0194, Japan.
FAU - Thi Le, Xoan
AU  - Thi Le X
AD  - Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, 
      Toyama 930-0194, Japan.
FAU - Fujiwara, Hironori
AU  - Fujiwara H
AD  - Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, 
      Toyama 930-0194, Japan.
FAU - Ishikawa, Tsutomu
AU  - Ishikawa T
AD  - Graduate School of Pharmaceutical Sciences, 1-8-1 Inohana, Chuo-ku, Chiba 
      260-8675, Japan.
FAU - Higuchi, Yoshihiro
AU  - Higuchi Y
AD  - Material Development Laboratories, Shiratori Pharmaceutical Co. Ltd., 6-11-24 
      Tsudanuma, Narashino, Chiba 275-0016, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140823
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - *Butea
MH  - CREB-Binding Protein/metabolism
MH  - Chronic Disease
MH  - Corticosterone/metabolism
MH  - Hippocampus/metabolism
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - Male
MH  - Mice
MH  - Pituitary-Adrenal System/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Plants, Medicinal
MH  - RNA, Messenger/biosynthesis
MH  - Stress, Psychological/*drug therapy
OTO - NOTNLM
OT  - Butea superba
OT  - Depression-like symptoms
OT  - Neurogenesis
OT  - Synaptic plasticity-related signaling
OT  - Unpredictable chronic mild stress
EDAT- 2014/08/26 06:00
MHDA- 2015/07/28 06:00
CRDT- 2014/08/26 06:00
PHST- 2014/06/05 00:00 [received]
PHST- 2014/08/12 00:00 [revised]
PHST- 2014/08/12 00:00 [accepted]
PHST- 2014/08/26 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
AID - S0378-8741(14)00608-4 [pii]
AID - 10.1016/j.jep.2014.08.014 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2014 Oct 28;156:16-25. doi: 10.1016/j.jep.2014.08.014. Epub 
      2014 Aug 23.