PMID- 25152500
OWN - NLM
STAT- MEDLINE
DCOM- 20150204
LR  - 20220330
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 6
DP  - 2014 Dec
TI  - Sensitivity and specificity of spectral-domain optical coherence tomography in 
      detecting idiopathic polypoidal choroidal vasculopathy.
PG  - 1228-1238.e1
LID - S0002-9394(14)00527-3 [pii]
LID - 10.1016/j.ajo.2014.08.025 [doi]
AB  - PURPOSE: To evaluate the efficacy of spectral-domain optical coherence tomography 
      (SD OCT) compared to indocyanine green angiography (ICGA) in detecting idiopathic 
      polypoidal choroidal vasculopathy (PCV) and in differentiating between PCV and 
      occult choroidal neovascularization (CNV). DESIGN: Retrospective observational 
      case-control study. METHODS: SD OCTs of 51 eyes of 44 consecutive patients who 
      presented with 1 or more pigment epithelial detachments (PEDs) attributable to 
      either PCV or occult CNV were retrospectively reviewed by a grader masked to the 
      final diagnosis. A qualitative analysis based on the following tomographic 
      findings was performed: sharp PED peak, PED notch, hyporeflective lumen within 
      hyperreflective lesions adherent to retinal pigment epithelium. The diagnosis 
      based on SD OCT alone was compared with the final diagnosis made using ICGA and 
      fluorescein angiography. Sensitivity and specificity were calculated. Patients 
      with classic CNV and central serous chorioretinopathy were excluded. RESULTS: 
      Among 51 eyes of 44 patients, 37 had an ICGA-confirmed diagnosis of PCV and 14 
      had occult CNV. SD OCT based on the features above detected 35 of 37 
      true-positive PCV lesions but missed 2 ICGA-confirmed lesions (false negatives). 
      SD OCT correctly excluded 13 of 14 non-PCV lesions but misidentified 1 PCV lesion 
      (false positive). These data showed a sensitivity of 94.6% and a specificity of 
      92.9% for the above SD OCT features in identifying PCV lesions. CONCLUSIONS: SD 
      OCT based on the features above allowed for good detection of PCV and 
      differentiation between PCV and occult CNV in this selected clinic population. A 
      careful qualitative analysis of the tomographic findings in patients presenting 
      with PEDs may allow ophthalmologists to distinguish between PCV and occult CNV, 
      decreasing the need for ICGA and the risks related to this procedure.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - De Salvo, Gabriella
AU  - De Salvo G
AD  - Medical Retina Department, Moorfields Eye Hospital National Health Service 
      Foundation Trust; and National Institute of Health Research Biomedical Research 
      Centre at Moorfields Eye Hospital National Health System Foundation Trust and 
      University College London Institute of Ophthalmology, London, United Kingdom. 
      Electronic address: gabrydsl@tiscali.it.
FAU - Vaz-Pereira, Sara
AU  - Vaz-Pereira S
AD  - Medical Retina Department, Moorfields Eye Hospital National Health Service 
      Foundation Trust; and National Institute of Health Research Biomedical Research 
      Centre at Moorfields Eye Hospital National Health System Foundation Trust and 
      University College London Institute of Ophthalmology, London, United Kingdom.
FAU - Keane, Pearse A
AU  - Keane PA
AD  - Medical Retina Department, Moorfields Eye Hospital National Health Service 
      Foundation Trust; and National Institute of Health Research Biomedical Research 
      Centre at Moorfields Eye Hospital National Health System Foundation Trust and 
      University College London Institute of Ophthalmology, London, United Kingdom.
FAU - Tufail, Adnan
AU  - Tufail A
AD  - Medical Retina Department, Moorfields Eye Hospital National Health Service 
      Foundation Trust; and National Institute of Health Research Biomedical Research 
      Centre at Moorfields Eye Hospital National Health System Foundation Trust and 
      University College London Institute of Ophthalmology, London, United Kingdom.
FAU - Liew, Gerald
AU  - Liew G
AD  - Medical Retina Department, Moorfields Eye Hospital National Health Service 
      Foundation Trust; and National Institute of Health Research Biomedical Research 
      Centre at Moorfields Eye Hospital National Health System Foundation Trust and 
      University College London Institute of Ophthalmology, London, United Kingdom.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140822
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
CIN - Am J Ophthalmol. 2015 Jul;160(1):203-4. PMID: 26054468
CIN - Am J Ophthalmol. 2015 Jul;160(1):204-5. PMID: 26054470
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Choroid/blood supply
MH  - Choroidal Neovascularization/*diagnosis
MH  - Coloring Agents
MH  - False Positive Reactions
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green
MH  - Male
MH  - Middle Aged
MH  - Polyps/*diagnosis
MH  - Predictive Value of Tests
MH  - Retinal Pigment Epithelium/pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
EDAT- 2014/08/26 06:00
MHDA- 2015/02/05 06:00
CRDT- 2014/08/26 06:00
PHST- 2014/04/18 00:00 [received]
PHST- 2014/08/16 00:00 [revised]
PHST- 2014/08/18 00:00 [accepted]
PHST- 2014/08/26 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/02/05 06:00 [medline]
AID - S0002-9394(14)00527-3 [pii]
AID - 10.1016/j.ajo.2014.08.025 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Dec;158(6):1228-1238.e1. doi: 10.1016/j.ajo.2014.08.025. 
      Epub 2014 Aug 22.