PMID- 25153173
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20151119
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 62
IP  - 36
DP  - 2014 Sep 10
TI  - Determining mycotoxins in baby foods and animal feeds using stable isotope 
      dilution and liquid chromatography tandem mass spectrometry.
PG  - 8935-43
LID - 10.1021/jf503943r [doi]
AB  - We developed a stable isotope dilution assay with liquid chromatography tandem 
      mass spectrometry (LC-MS/MS) to determine multiple mycotoxins in baby foods and 
      animal feeds. Samples were fortified with [(13)C]-uniformly labeled mycotoxins as 
      internal standards ([(13)C]-IS) and prepared by solvent extraction (50% 
      acetonitrile in water) and filtration, followed by LC-MS/MS analysis. Mycotoxins 
      in each sample were quantitated with the corresponding [(13)C]-IS. In general, 
      recoveries of aflatoxins (2-100 ng/g), deoxynivalenol, fumonisins (50-2000 ng/g), 
      ochratoxin A (20-1000 ng/kg), T-2 toxin, and zearalenone (40-2000 ng/g) in tested 
      matrices (grain/rice/oatmeal-based formula, animal feed, dry cat/dog food) ranged 
      from 70 to 120% with relative standard deviations (RSDs) <20%. The method 
      provides sufficient selectivity, sensitivity, accuracy, and reproducibility to 
      screen for aflatoxins at ng/g concentrations and deoxynivalenol and fumonisins at 
      low mug/g concentrations in baby foods and animal feeds, without using 
      conventional standard addition or matrix-matched calibration standards to correct 
      for matrix effects.
FAU - Zhang, Kai
AU  - Zhang K
AD  - Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. 
      Food and Drug Administration , HFS-706, 5100 Paint Branch Parkway, College Park, 
      Maryland 20740, United States.
FAU - Wong, Jon W
AU  - Wong JW
FAU - Krynitsky, Alexander J
AU  - Krynitsky AJ
FAU - Trucksess, Mary W
AU  - Trucksess MW
LA  - eng
PT  - Journal Article
DEP - 20140902
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Aflatoxins)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Fumonisins)
RN  - 0 (Mycotoxins)
RN  - 0 (Ochratoxins)
RN  - 0 (Trichothecenes)
RN  - 1779SX6LUY (ochratoxin A)
RN  - I3FL5NM3MO (T-2 Toxin)
RN  - JT37HYP23V (deoxynivalenol)
SB  - IM
MH  - Aflatoxins/analysis
MH  - Animal Feed/*analysis
MH  - Animals
MH  - Carbon Isotopes
MH  - Cats
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Dogs
MH  - Fumonisins/analysis
MH  - Humans
MH  - Indicator Dilution Techniques
MH  - Infant
MH  - Infant Food/*analysis
MH  - Mycotoxins/*analysis
MH  - Ochratoxins/analysis
MH  - Reproducibility of Results
MH  - T-2 Toxin/analysis
MH  - Tandem Mass Spectrometry/*methods
MH  - Trichothecenes/analysis
OTO - NOTNLM
OT  - LC-MS/MS
OT  - animal feeds
OT  - baby foods
OT  - mycotoxins
OT  - stable isotope dilution
EDAT- 2014/08/26 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/08/26 06:00
PHST- 2014/08/26 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.1021/jf503943r [doi]
PST - ppublish
SO  - J Agric Food Chem. 2014 Sep 10;62(36):8935-43. doi: 10.1021/jf503943r. Epub 2014 
      Sep 2.