PMID- 25153796 OWN - NLM STAT- MEDLINE DCOM- 20151218 LR - 20220331 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 9 IP - 8 DP - 2014 TI - Plasma brain-derived neurotrophic factor and reverse dipping pattern of nocturnal blood pressure in patients with cardiovascular risk factors. PG - e105977 LID - 10.1371/journal.pone.0105977 [doi] LID - e105977 AB - CONTEXT: Basic studies have shown that brain-derived neurotrophic factor (BDNF) has critical roles in the survival, growth, maintenance, and death of central and peripheral neurons, while it is also involved in regulation of the autonomic nervous system. Furthermore, recent clinical studies have suggested potential role of plasma BDNF in the circulatory system. OBJECTIVE: We investigated the mutual relationships among plasma BDNF, patterns of nocturnal blood pressure changes (dippers, non-dippers, extra-dippers, and reverse-dippers), and cardiac autonomic function as determined by heart rate variability (HRV). DESIGN: This was a cross-sectional study of patients registered in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) Study from October 2010 to November 2012. PATIENTS: Two-hundred fifty patients with 1 or more cardiovascular risk factor(s) (obesity, smoking, presence of cardiovascular event history, hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease) were enrolled. RESULTS: Plasma BDNF levels (natural logarithm transformed) were significantly (p = 0.001) lower in reverse-dipper patients (7.18+/-0.69 pg/ml, mean +/- SD, n = 36) as compared to dippers (7.86+/-0.86 pg/ml, n = 100). Multiple logistic regression analysis showed that BDNF (odds ratios: 0.417, 95% confidence interval: 0.228-0.762, P = 0.004) was the sole factor significantly and independently associated with the reverse-dippers as compared with dippers. Furthermore, plasma BDNF level was significantly and positively correlated with the time-domain (SDNN, SDANN5, CVRR) and frequency-domain (LF) of HRV parameters. Finally, multiple logistic regression analyses showed that the relationship between plasma BDNF and the reverse-dippers was weakened, yet remained significant or borderline significant even after adjusting for HRV parameters. CONCLUSIONS: Low plasma BDNF was independently associated with patients showing a reverse-dipper pattern of nocturnal blood pressure, in which an imbalance of cardiac autonomic function may be partly involved. FAU - Kadoya, Manabu AU - Kadoya M AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Koyama, Hidenori AU - Koyama H AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Kanzaki, Akinori AU - Kanzaki A AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Kurajoh, Masafumi AU - Kurajoh M AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Hatayama, Miki AU - Hatayama M AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Shiraishi, Jun AU - Shiraishi J AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Okazaki, Hirokazu AU - Okazaki H AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Shoji, Takuhito AU - Shoji T AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Moriwaki, Yuji AU - Moriwaki Y AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Yamamoto, Tetsuya AU - Yamamoto T AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Inaba, Masaaki AU - Inaba M AD - Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. FAU - Namba, Mitsuyoshi AU - Namba M AD - Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Autonomic Nervous System/physiopathology MH - Blood Pressure/*physiology MH - Blood Pressure Determination/methods MH - Blood Pressure Monitoring, Ambulatory/methods MH - Brain-Derived Neurotrophic Factor/*blood MH - Cardiovascular Diseases/*blood/*physiopathology MH - Cross-Sectional Studies MH - Female MH - Heart Rate/physiology MH - Humans MH - Hypertension/blood/physiopathology MH - Male MH - Middle Aged MH - Risk Factors PMC - PMC4143316 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2014/08/26 06:00 MHDA- 2015/12/19 06:00 PMCR- 2014/08/25 CRDT- 2014/08/26 06:00 PHST- 2014/05/27 00:00 [received] PHST- 2014/07/25 00:00 [accepted] PHST- 2014/08/26 06:00 [entrez] PHST- 2014/08/26 06:00 [pubmed] PHST- 2015/12/19 06:00 [medline] PHST- 2014/08/25 00:00 [pmc-release] AID - PONE-D-14-23522 [pii] AID - 10.1371/journal.pone.0105977 [doi] PST - epublish SO - PLoS One. 2014 Aug 25;9(8):e105977. doi: 10.1371/journal.pone.0105977. eCollection 2014.