PMID- 25154422
OWN - NLM
STAT- MEDLINE
DCOM- 20160412
LR  - 20150714
IS  - 1464-5033 (Electronic)
IS  - 0301-4460 (Linking)
VI  - 42
IP  - 3
DP  - 2015
TI  - Monocyte chemoattractant protein-1 (MCP-1) g.-2518A>G polymorphism and 
      susceptibility to type 2 diabetes (T2D) and end stage renal disease (ESRD) in the 
      North-West Indian population of Punjab.
PG  - 276-82
LID - 10.3109/03014460.2014.941932 [doi]
AB  - BACKGROUND: Diabetic nephropathy (DN) is a major microvascular complication that 
      develops in nearly 20-30% of patients with type 2 diabetes (T2D) and is currently 
      the leading cause of end stage renal disease (ESRD). Monocyte chemoattractant 
      protein-1 (MCP-1), a potent chemokine secreted by adipocytes, has been implicated 
      as a causal factor in the progression of vascular complications in T2D, thus 
      MCP-1 appears to be a promising candidate for association study. AIM: The 
      objective of the present study is to evaluate the association, if any, of 
      g.-2518A>G polymorphism (rs1024611) in MCP-1 gene in T2D cases with and without 
      ESRD in the population of Punjab from North-West India. SUBJECTS AND METHODS: A 
      total of 571 samples from Punjab comprising 350 T2D cases (145 with ESRD and 205 
      without ESRD) and 221 controls were genotyped for g.-2518A>G MCP-1 polymorphism 
      using amplification refractory mutation system- polymerase chain reaction. 
      RESULTS: The frequency of G allele was observed to be higher in T2D cases with 
      ESRD (34.49%) compared to T2D cases without ESRD (24.39%) and controls (31.67%). 
      Under the dominant model, G allele increased the risk of ESRD by 1.68-fold 
      [p = 0.047, OR = 1.68 (1.0-2.79) at 95% CI]. CONCLUSION: MCP-1 -2518 GG genotype 
      and G allele may increase the risk of progression to ESRD in T2D cases.
FAU - Raina, Priyanka
AU  - Raina P
AD  - Department of Human Genetics, Guru Nanak Dev University , Amritsar, Punjab , 
      India.
FAU - Matharoo, Kawaljit
AU  - Matharoo K
FAU - Bhanwer, A J S
AU  - Bhanwer AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140826
PL  - England
TA  - Ann Hum Biol
JT  - Annals of human biology
JID - 0404024
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics/metabolism
MH  - Diabetes Mellitus, Type 2/*epidemiology/genetics
MH  - Disease Susceptibility/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Kidney Failure, Chronic/*epidemiology/genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
OTO - NOTNLM
OT  - Association analysis
OT  - ESRD
OT  - MCP-1
OT  - T2D
OT  - survival analysis
EDAT- 2014/08/27 06:00
MHDA- 2016/04/14 06:00
CRDT- 2014/08/27 06:00
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - 10.3109/03014460.2014.941932 [doi]
PST - ppublish
SO  - Ann Hum Biol. 2015;42(3):276-82. doi: 10.3109/03014460.2014.941932. Epub 2014 Aug 
      26.