PMID- 25154991
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20181202
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 94
IP  - 24
DP  - 2014 Jun 24
TI  - [Decreased hypoxic ventilatory chemoresponsiveness and clinical features in 
      patients with narcolepsy cataplexy].
PG  - 1870-3
AB  - OBJECTIVE: To explore the relationship between hypoxic responsiveness of the 
      patients with narcolepsy-cataplexy and their clinical features. METHODS: A total 
      of 113 patients with narcolepsy-cataplexy (narcolepsy group) at Peking University 
      People's Hospital from June 2007 to May 2008 and 128 gender-age matched 
      volunteers (control group) were recruited. And their status of human leukocyte 
      antigen (HLA)-DQB1*0602 was examined to differentiate hypercapnic and hypoxic 
      responsiveness. Among them, 93 patients with severe hypersomnolence had 
      hypercapnic and hypoxic responsiveness tested before and after the treatment of 
      methylphenidate and another 20 with severe cataplexy did the same before and 
      after the treatment of chlorimiopramine. RESULTS: Compared with the control 
      group, the narcolepsy group had depressed hypoxic responsiveness ((-0.135 +/- 
      0.105) vs (-0.223 +/- 0.136) Lxmin(-)(1) x %SpO(2)(-)(1), P < 0.001). After the treatment of 
      methylphenidate, sleepiness improved significantly in all 93 patients, but their 
      low hypoxic responsiveness did not change ((-0.151 +/- 0.111) vs (-0.149 +/- 0.105) 
      Lxmin(-)(1)x % SpO(2)(-)(1), P = 0.780). After the treatment of chlorimiopramine, cataplexy 
      also improved in 20 patients.However their low hypoxic responsiveness had no 
      change ((-0.114 +/- 0.054) vs (-0.115 +/- 0.065) Lxmin(-)(1) x %SpO(2)(-)(1), P = 0.949). 
      CONCLUSION: Lower hypoxic responsiveness in narcolepsy group is not related with 
      the clinical features of disease.
FAU - Zhang, Xiaozhe
AU  - Zhang X
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China.
FAU - Dong, Xiaosong
AU  - Dong X
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China.
FAU - Han, Fang
AU  - Han F
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China. Email: hanfang1@hotmail.com.
FAU - Yan, Han
AU  - Yan H
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China.
FAU - An, Pei
AU  - An P
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China.
FAU - Zhao, Long
AU  - Zhao L
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China.
FAU - Gao, Zhancheng
AU  - Gao Z
AD  - Department of Respiratory & Critical Care Medicine, Peking University People's 
      Hospital, Beijing 100044, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (HLA-DQ beta-Chains)
SB  - IM
MH  - *Cataplexy
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Hypercapnia
MH  - *Hypoxia
EDAT- 2014/08/27 06:00
MHDA- 2015/09/09 06:00
CRDT- 2014/08/27 06:00
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2014 Jun 24;94(24):1870-3.