PMID- 25155878
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20211021
IS  - 1476-5578 (Electronic)
IS  - 1359-4184 (Linking)
VI  - 20
IP  - 5
DP  - 2015 May
TI  - Chronic depression is associated with a pronounced decrease in serum 
      brain-derived neurotrophic factor over time.
PG  - 602-8
LID - 10.1038/mp.2014.83 [doi]
AB  - One of the leading neurobiological hypotheses on depression states that decreased 
      expression of brain-derived neurotrophic factor (BDNF) contributes to depression. 
      This is supported by consistent findings of low serum BDNF levels in depressed 
      patients compared with non-depressed controls. Whereas it has been generally 
      assumed that this is a state characteristic of depression, strong inferences 
      about state or trait effects require a longitudinal study design. To investigate 
      the longitudinal association between serum BDNF and depression, we measured serum 
      BDNF, (current and past) depression status, use of antidepressants, and all 
      potential covariates at baseline and after 2 years in 1751 individuals, 
      consisting of patients with an incident (n=153), remitted (n=420) and persistent 
      depression (n=310) and non-depressed controls (n=868). We analyzed 
      change/differences in serum BDNF across these four groups with analyses of 
      covariance adjusted for covariates and baseline BDNF value, together with the 
      effects of starting and stopping antidepressant treatment. Our analyses revealed 
      a significant difference for the depression course groups (P=0.007). Compared 
      with non-depressed controls, persistently depressed and remitted patients had a 
      steeper decrease of BDNF levels over time (-1.33 (P=0.001) and -0.97 ng ml(-1) 
      (P=0.011), respectively), whereas BDNF reductions in patients with incident 
      depression were similar to those in healthy controls. Initiation or 
      discontinuation of antidepressants was not associated with BDNF change (P=0.72). 
      These findings suggest that BDNF not only contributes to depression, but that 
      depression in turn may also contribute to low BDNF.
FAU - Bus, B A A
AU  - Bus BA
AD  - Department of Psychiatry, Nijmegen Centre for Evidence Based Practice (NCEBP) 
      Radboud University Medical Centre, Nijmegen, The Netherlands.
FAU - Molendijk, M L
AU  - Molendijk ML
AD  - Clinical, Health and Neuropsychology Unit, Leiden University, Leiden, the 
      Netherlands and Leiden Institute for Brain and Cognition, Leiden University 
      Medical Center, Leiden, The Netherlands.
FAU - Tendolkar, I
AU  - Tendolkar I
AD  - 1] Department of Psychiatry, Nijmegen Centre for Evidence Based Practice (NCEBP) 
      Radboud University Medical Centre, Nijmegen, The Netherlands [2] Faculty of 
      Medicine and LVR Clinic for Psychiatry and Psychotherapy, University of 
      Duisburg-Essen, Germany [3] Donders Institute for Brain Cognition and Behaviour, 
      Centre for Neuroscience, Nijmegen, The Netherlands.
FAU - Penninx, B W J H
AU  - Penninx BW
AD  - 1] Department of Psychiatry and EMGO Institute, VU University Medical Center, 
      Amsterdam, The Netherlands [2] Department of Psychiatry, Leiden University 
      Medical Center, Leiden, The Netherlands [3] Department of Psychiatry, University 
      Medical Center Groningen, Groningen, The Netherlands.
FAU - Prickaerts, J
AU  - Prickaerts J
AD  - Department of Psychiatry and Neuropsychology, School for Mental Health and 
      Neuroscience, Maastricht University, Maastricht, The Netherlands.
FAU - Elzinga, B M
AU  - Elzinga BM
AD  - Clinical, Health and Neuropsychology Unit, Leiden University, Leiden, the 
      Netherlands and Leiden Institute for Brain and Cognition, Leiden University 
      Medical Center, Leiden, The Netherlands.
FAU - Voshaar, R C O
AU  - Voshaar RC
AD  - 1] Department of Psychiatry, Nijmegen Centre for Evidence Based Practice (NCEBP) 
      Radboud University Medical Centre, Nijmegen, The Netherlands [2] Department of 
      Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140826
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child Abuse/psychology
MH  - Chronic Disease
MH  - Depression/*blood/classification/drug therapy
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2014/08/27 06:00
MHDA- 2016/01/20 06:00
CRDT- 2014/08/27 06:00
PHST- 2014/01/06 00:00 [received]
PHST- 2014/05/02 00:00 [revised]
PHST- 2014/06/17 00:00 [accepted]
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
AID - mp201483 [pii]
AID - 10.1038/mp.2014.83 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2015 May;20(5):602-8. doi: 10.1038/mp.2014.83. Epub 2014 Aug 26.