PMID- 25156382
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20220311
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 40
IP  - 9
DP  - 2014 Nov
TI  - Hippocampal brain-derived neurotrophic factor mediates recovery from chronic 
      stress-induced spatial reference memory deficits.
PG  - 3351-62
LID - 10.1111/ejn.12703 [doi]
AB  - Chronic restraint stress impairs hippocampal-mediated spatial learning and 
      memory, which improves following a post-stress recovery period. Here, we 
      investigated whether brain-derived neurotrophic factor (BDNF), a protein 
      important for hippocampal function, would alter the recovery from chronic 
      stress-induced spatial memory deficits. Adult male Sprague-Dawley rats were 
      infused into the dorsal hippocampal cornu ammonis (CA)3 region with an 
      adeno-associated viral vector containing the sequence for a short hairpin RNA 
      (shRNA) directed against BDNF or a scrambled sequence (Scr). Rats were then 
      chronically restrained (wire mesh, 6 h/day for 21 days) and assessed for spatial 
      learning and memory using a radial arm water maze (RAWM) either immediately after 
      stressor cessation (Str-Imm) or following a 21-day post-stress recovery period 
      (Str-Rec). All groups learned the RAWM task similarly, but differed on the memory 
      retention trials. Rats in the Str-Imm group, regardless of adeno-associated viral 
      contents, committed more errors in the spatial reference memory domain on the 
      single retention trial during day 3 than did the non-stressed controls. 
      Importantly, the typical improvement in spatial memory following the recovery 
      from chronic stress was blocked with the shRNA against BDNF, as Str-Rec-shRNA 
      performed worse on the RAWM compared with the non-stressed controls or 
      Str-Rec-Scr. The stress effects were specific for the reference memory domain, 
      but knockdown of hippocampal BDNF in unstressed controls briefly disrupted 
      spatial working memory as measured by repeated entry errors on day 2 of training. 
      These results demonstrated that hippocampal BDNF was necessary for the recovery 
      from stress-induced hippocampal-dependent spatial memory deficits in the 
      reference memory domain.
CI  - (c) 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Ortiz, J Bryce
AU  - Ortiz JB
AD  - Behavioral Neuroscience, Department of Psychology, Arizona State University, Box 
      1104, Tempe, AZ, 85287-1104, USA.
FAU - Mathewson, Coy M
AU  - Mathewson CM
FAU - Hoffman, Ann N
AU  - Hoffman AN
FAU - Hanavan, Paul D
AU  - Hanavan PD
FAU - Terwilliger, Ernest F
AU  - Terwilliger EF
FAU - Conrad, Cheryl D
AU  - Conrad CD
LA  - eng
GR  - R25GM099650/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140825
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - CA3 Region, Hippocampal/*metabolism
MH  - Down-Regulation
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Spatial Memory/*physiology
MH  - Stress, Psychological/*metabolism
OTO - NOTNLM
OT  - neuroplasticity
OT  - radial arm water maze
OT  - rat
OT  - recovery of function
OT  - resilience
OT  - short hairpin RNA
EDAT- 2014/08/27 06:00
MHDA- 2015/06/26 06:00
CRDT- 2014/08/27 06:00
PHST- 2014/02/27 00:00 [received]
PHST- 2014/07/22 00:00 [revised]
PHST- 2014/07/24 00:00 [accepted]
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - 10.1111/ejn.12703 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2014 Nov;40(9):3351-62. doi: 10.1111/ejn.12703. Epub 2014 Aug 25.