PMID- 25156475
OWN - NLM
STAT- MEDLINE
DCOM- 20150528
LR  - 20161125
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 53
IP  - 41
DP  - 2014 Oct 6
TI  - Flavin redox bifurcation as a mechanism for controlling the direction of electron 
      flow during extracellular electron transfer.
PG  - 10988-91
LID - 10.1002/anie.201407004 [doi]
AB  - The iron-reducing bacterium Shewanella oneidensis MR-1 has a dual directional 
      electronic conduit involving 40 heme redox centers in flavin-binding 
      outer-membrane c-type cytochromes (OM c-Cyts). While the mechanism for electron 
      export from the OM c-Cyts to an anode is well understood, how the redox centers 
      in OM c-Cyts take electrons from a cathode has not been elucidated at the 
      molecular level. Electrochemical analysis of live cells during switching from 
      anodic to cathodic conditions showed that altering the direction of electron flow 
      does not require gene expression or protein synthesis, but simply redox potential 
      shift about 300 mV for a flavin cofactor interacting with the OM c-Cyts. That is, 
      the redox bifurcation of the riboflavin cofactor in OM c-Cyts switches the 
      direction of electron conduction in the biological conduit at the cell-electrode 
      interface to drive bacterial metabolism as either anode or cathode catalysts.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Okamoto, Akihiro
AU  - Okamoto A
AD  - Department of Applied Chemistry, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 
      Tokyo 113-8656 (Japan). okamoto@light.t.u-tokyo.ac.jp.
FAU - Hashimoto, Kazuhito
AU  - Hashimoto K
FAU - Nealson, Kenneth H
AU  - Nealson KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140826
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 0 (Benzoquinones)
RN  - 0 (Flavins)
RN  - 0 (Hydroquinones)
RN  - 9007-43-6 (Cytochromes c)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
RN  - XV74C1N1AE (hydroquinone)
SB  - IM
MH  - Benzoquinones/chemistry
MH  - Cytochromes c/chemistry/metabolism
MH  - Electrodes
MH  - Electron Transport
MH  - Electrons
MH  - Flavins/*chemistry
MH  - Geobacter/metabolism
MH  - Hydroquinones/chemistry
MH  - Oxidation-Reduction
MH  - Succinate Dehydrogenase/chemistry/metabolism
OTO - NOTNLM
OT  - cytochromes
OT  - electron transfer
OT  - in vivo studies
OT  - microbial electrosynthesis
OT  - riboflavins
EDAT- 2014/08/27 06:00
MHDA- 2015/05/29 06:00
CRDT- 2014/08/27 06:00
PHST- 2014/07/08 00:00 [received]
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2015/05/29 06:00 [medline]
AID - 10.1002/anie.201407004 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10988-91. doi: 10.1002/anie.201407004. 
      Epub 2014 Aug 26.