PMID- 25156535
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 41
IP  - 12
DP  - 2014 Dec
TI  - HLA DQB1 alleles are related with nonalcoholic fatty liver disease.
PG  - 7937-43
LID - 10.1007/s11033-014-3688-2 [doi]
AB  - Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver 
      disease. NAFLD is a complex disease and inflammation is a crucial component in 
      the disease pathogenesis. Recent genome wide association studies in hepatology 
      area highlighted significant relations with human leukocyte antigen (HLA) DQ 
      region and certain liver diseases. The previous animal models also emphasized the 
      involvement of adaptive immune system in the liver damage pathways. To 
      investigate possible polymorphisms in the HLA region that can contribute to the 
      immune response affecting the NAFLD, we enrolled 93 consecutive biopsy proven 
      NAFLD patients and a control group consisted of 101 healthy people and genotyped 
      HLA DQB1 alleles at high resolution by sequence specific primers-polymerase chain 
      reaction. The mean NAFLD activity score (NAS) was 5.2 +/- 1.2, fibrosis score was 
      0.9 +/- 0.9, ALT was 77 +/- 47.4 U/L, AST was 49.4 +/- 26.3 U/L. Among 13 HLA DQB1 
      alleles analyzed in this study, DQB1*06:04 was observed significantly at a more 
      frequent rate among the NAFLD patients compared to that of healthy controls (12.9 
      vs. 2 % chi(2) = 8.6, P = 0.003, P c = 0.039, OR: 7.3 95 % CI 1.6-33.7). In 
      addition, the frequency of DQB1*03:02 was significantly higher in the healthy 
      control group than the NAFLD patients (24.8 vs. 7.5 %, chi(2) = 10.4, P = 0.001, P 
      c = 0.013, OR: 0.2, 95 % CI 0.1-0.6). NAFLD patients were grouped according to 
      their fibrosis score and NAS. The distribution of DQB1 alleles over stratified 
      NAFLD patients did not reveal any statistically significant relation. Taken 
      together, immune repertoire of individuals may have an effect on NAFLD 
      pathogenesis and therefore, in NAFLD, adaptive immunity pathways should be 
      investigated.
FAU - Doganay, Levent
AU  - Doganay L
AD  - Department of Gastroenterology, Goztepe Teaching and Research Hospital, Medeniyet 
      University, Istanbul, Turkey, levent.doganay@ueh.gov.tr.
FAU - Katrinli, Seyma
AU  - Katrinli S
FAU - Colak, Yasar
AU  - Colak Y
FAU - Senates, Ebubekir
AU  - Senates E
FAU - Zemheri, Ebru
AU  - Zemheri E
FAU - Ozturk, Oguzhan
AU  - Ozturk O
FAU - Enc, Feruze Yilmaz
AU  - Enc FY
FAU - Tuncer, Ilyas
AU  - Tuncer I
FAU - Doganay, Gizem Dinler
AU  - Doganay GD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140826
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*genetics
MH  - Polymorphism, Genetic
EDAT- 2014/08/27 06:00
MHDA- 2016/06/09 06:00
CRDT- 2014/08/27 06:00
PHST- 2013/09/21 00:00 [received]
PHST- 2014/08/20 00:00 [accepted]
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 10.1007/s11033-014-3688-2 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2014 Dec;41(12):7937-43. doi: 10.1007/s11033-014-3688-2. Epub 2014 
      Aug 26.