PMID- 25156590
OWN - NLM
STAT- MEDLINE
DCOM- 20160503
LR  - 20231110
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Print)
IS  - 2192-2640 (Linking)
VI  - 4
IP  - 3
DP  - 2015 Feb 18
TI  - Monocyte-targeting supramolecular micellar assemblies: a molecular diagnostic 
      tool for atherosclerosis.
PG  - 367-76
LID - 10.1002/adhm.201400336 [doi]
AB  - Atherosclerosis is a multifactorial inflammatory disease that can progress 
      silently for decades and result in myocardial infarction, stroke, and death. 
      Diagnostic imaging technologies have made great strides to define the degree of 
      atherosclerotic plaque burden through the severity of arterial stenosis. However, 
      current technologies cannot differentiate more lethal "vulnerable plaques," and 
      are not sensitive enough for preventive medicine. Imaging early molecular markers 
      and quantifying the extent of disease progression continues to be a major 
      challenge in the field. To this end, monocyte-targeting, peptide amphiphile 
      micelles (PAMs) are engineered through the incorporation of the chemokine 
      receptor CCR2-binding motif of monocyte chemoattractant protein-1 (MCP-1) and 
      MCP-1 PAMs are evaluated preclinically as diagnostic tools for atherosclerosis. 
      Monocyte-targeting is desirable as the influx of monocytes is a marker of early 
      lesions, accumulation of monocytes is linked to atherosclerosis progression, and 
      rupture-prone plaques have higher numbers of monocytes. MCP-1 PAMs bind to 
      monocytes in vitro, and MCP-1 PAMs detect and discriminate between early- and 
      late-stage atherosclerotic aortas. Moreover, MCP-1 PAMs are found to be 
      eliminated via renal clearance and the mononuclear phagocyte system (MPS) without 
      adverse side effects. Thus, MCP-1 PAMs are a promising new class of diagnostic 
      agents capable of monitoring the progression of atherosclerosis.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Chung, Eun Ji
AU  - Chung EJ
AD  - Institute for Molecular Engineering, University of Chicago, 5747 S. Ellis Ave, 
      Chicago, IL, 60637, USA.
FAU - Mlinar, Laurie B
AU  - Mlinar LB
FAU - Nord, Kathryn
AU  - Nord K
FAU - Sugimoto, Matthew J
AU  - Sugimoto MJ
FAU - Wonder, Emily
AU  - Wonder E
FAU - Alenghat, Francis J
AU  - Alenghat FJ
FAU - Fang, Yun
AU  - Fang Y
FAU - Tirrell, Matthew
AU  - Tirrell M
LA  - eng
GR  - K08 HL116600/HL/NHLBI NIH HHS/United States
GR  - R00 HL103789/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000430/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140822
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Apolipoproteins E)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Micelles)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apolipoproteins E/genetics
MH  - Atherosclerosis/*diagnosis/metabolism/pathology
MH  - Binding Sites
MH  - Chemokine CCL2/chemistry/*metabolism/pharmacokinetics
MH  - Drug Evaluation, Preclinical/methods
MH  - Female
MH  - Macrophages
MH  - Mice, Transgenic
MH  - Micelles
MH  - Molecular Sequence Data
MH  - Monocytes/*metabolism
MH  - Pathology, Molecular/methods
MH  - Receptors, CCR2/metabolism
MH  - Recombinant Proteins/genetics/metabolism/pharmacokinetics
MH  - Tissue Distribution
PMC - PMC4336846
MID - NIHMS632144
OTO - NOTNLM
OT  - atherosclerosis
OT  - molecular imaging
OT  - peptide amphiphiles
OT  - self-assembly
OT  - targeting
EDAT- 2014/08/27 06:00
MHDA- 2016/05/04 06:00
PMCR- 2015/02/24
CRDT- 2014/08/27 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/07/18 00:00 [revised]
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2016/05/04 06:00 [medline]
PHST- 2015/02/24 00:00 [pmc-release]
AID - 10.1002/adhm.201400336 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2015 Feb 18;4(3):367-76. doi: 10.1002/adhm.201400336. Epub 
      2014 Aug 22.