PMID- 25158008
OWN - NLM
STAT- MEDLINE
DCOM- 20160506
LR  - 20150813
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 125
IP  - 8
DP  - 2015
TI  - Cerebrovascular events in HIV-infected patients: an analysis of a cohort of 3203 
      HIV+ patients during the times of cART.
PG  - 601-11
LID - 10.3109/00207454.2014.956870 [doi]
AB  - PURPOSE/AIM: Cerebrovascular events (CVE) in HIV infected patients have become an 
      increasingly relevant neurological complication. Data about the prevalence and 
      clinical features of CVE in HIV infected patients since the introduction of 
      combined Anti-Retroviral Therapy (cART) are rare. METHODS: A retrospective study 
      of HIV-infected patients with a CVE was performed from 2002 to 2011. During this 
      time period 3203 HIV-infected patients were admitted to the University hospital 
      of Munster, Germany. All patients had access to regular and long term treatment 
      with cART. The clinical features were analyzed and the prevalence of ischemic 
      stroke (IS), transient ischemic attack (TIA) and intracerebral bleeding (ICB) was 
      calculated. RESULTS: The total prevalence of all CVE was at 0.6% (95% CI: 0.3, 
      0.8) (0.4% for IS (95% CI: 0.2, 0.6), 0.2% for TIA (95% CI: 0.0, 0.3) and 0.1% 
      for ICB (95% CI: 0.0, 0.2)) and the crude annual incidence rate at 59 per 100.000 
      for all events. The median CD4 cell count was 405/mul (25th to 75th percentile: 
      251-568). The majority of patients had AIDS. The median age was at 49 years (25th 
      to 75th percentile: 40-69). Some events were associated with HIV-associated 
      vasculopathy or viral co-infections. Most patients presented with multiple 
      vascular risk factors. CONCLUSION: The study confirms that CVE occur in 
      HIV-infected patients with a good immune status and at a young age. HIV infection 
      has to be considered in young stroke patients. The rate of CVE in this study was 
      constant when comparing to the pre-cART era. HIV associated vasculopathy and 
      viral co-infections need to be considered in the diagnostics of stroke.
FAU - Arentzen, Max
AU  - Arentzen M
AD  - 1Department of Neurology, University of Munster, Germany.
FAU - Jubt, Franziska
AU  - Jubt F
FAU - Evers, Stefan
AU  - Evers S
FAU - Hesselmann, Volker
AU  - Hesselmann V
FAU - Fiori, Wolfgang
AU  - Fiori W
FAU - Reichelt, Doris
AU  - Reichelt D
FAU - Oelker-Grueneberg, Ute
AU  - Oelker-Grueneberg U
FAU - Schwindt, Wolfram
AU  - Schwindt W
FAU - Dziewas, Rainer
AU  - Dziewas R
FAU - Husstedt, Ingo-W
AU  - Husstedt IW
LA  - eng
PT  - Journal Article
DEP - 20140924
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Brain/pathology
MH  - CD4 Lymphocyte Count
MH  - Cerebrovascular Disorders/*chemically induced/diagnosis/*epidemiology
MH  - Cohort Studies
MH  - Female
MH  - Germany
MH  - HIV Infections/*drug therapy/*epidemiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - AIDS
OT  - HIV
OT  - HIV vasculopathy
OT  - TIA
OT  - cART
OT  - cerebrovascular disease
OT  - stroke
EDAT- 2014/08/27 06:00
MHDA- 2016/05/07 06:00
CRDT- 2014/08/27 06:00
PHST- 2014/08/27 06:00 [entrez]
PHST- 2014/08/27 06:00 [pubmed]
PHST- 2016/05/07 06:00 [medline]
AID - 10.3109/00207454.2014.956870 [doi]
PST - ppublish
SO  - Int J Neurosci. 2015;125(8):601-11. doi: 10.3109/00207454.2014.956870. Epub 2014 
      Sep 24.