PMID- 25158826
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20220318
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 11
DP  - 2014 Aug 27
TI  - Antiviral potency and functional analysis of tetherin orthologues encoded by 
      horse and donkey.
PG  - 151
LID - 10.1186/1743-422X-11-151 [doi]
LID - 151
AB  - BACKGROUND: Tetherin is an interferon-inducible host cell factor that blocks the 
      viral particle release of the enveloped viruses. Most knowledge regarding the 
      interaction between tetherin and viruses has been obtained using the primate 
      lentiviral system. However, much less is known about the functional roles of 
      tetherin on other lentiviruses. Equine infectious anemia virus (EIAV) is an 
      important macrophage-tropic lentivirus that has been widely used as a practical 
      model for investigating the evolution of the host-virus relationship. The host 
      range of EIAV is reported to include all members of the Equidae family. However, 
      EIAV has different clinical responses in horse and donkey. It's intriguing to 
      investigate the similarities and differences between the tetherin orthologues 
      encoded by horse and donkey. RESULTS: We report here that there are two equine 
      tetherin orthologues. Compared to horse tetherin, there are three valine amino 
      acid deletions within the transmembrane domain and three distinct mutations 
      within the ectodomain of donkey tetherin. However, the antiviral activity of 
      donkey tetherin was not affected by amino acid deletion or substitution. In 
      addition, both tetherin orthologues encoded by horse and donkey are similarly 
      sensitive to EIAV Env protein, and equally activate NF-kappaB signaling. CONCLUSION: 
      Our data suggest that both tetherin orthologues encoded by horse and donkey 
      showed similar antiviral activities and abilities to induce NF-kappaB signaling. In 
      addition, the phenomenon about the differential responses of horses and donkeys 
      to infection with EIAV was not related with the differences in the structure of 
      the corresponding tetherin orthologues.
FAU - Yin, Xin
AU  - Yin X
FAU - Guo, Miaomiao
AU  - Guo M
FAU - Gu, Qinyong
AU  - Gu Q
FAU - Wu, Xingliang
AU  - Wu X
FAU - Wei, Ping
AU  - Wei P
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, China. 
      weiiping@163.com.
FAU - Wang, Xiaojun
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140827
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (Antigens, CD)
RN  - 0 (Antiviral Agents)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, CD/genetics/metabolism/*pharmacology
MH  - Antiviral Agents/*pharmacology
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - Equidae/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Infectious Anemia Virus, Equine/*drug effects
MH  - Macrophages/metabolism
MH  - Membrane Glycoproteins/genetics/metabolism/*pharmacology
MH  - Molecular Sequence Data
MH  - Mutation
MH  - NF-kappa B/genetics/metabolism
MH  - Protein Isoforms
MH  - Signal Transduction
MH  - T-Lymphocytes/metabolism
PMC - PMC4152588
EDAT- 2014/08/28 06:00
MHDA- 2015/05/20 06:00
PMCR- 2014/08/27
CRDT- 2014/08/28 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2014/08/22 00:00 [accepted]
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PHST- 2014/08/27 00:00 [pmc-release]
AID - 1743-422X-11-151 [pii]
AID - 2480 [pii]
AID - 10.1186/1743-422X-11-151 [doi]
PST - epublish
SO  - Virol J. 2014 Aug 27;11:151. doi: 10.1186/1743-422X-11-151.