PMID- 25159674
OWN - NLM
STAT- MEDLINE
DCOM- 20150818
LR  - 20220410
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 43
IP  - 4
DP  - 2015
TI  - Conversion of mild cognitive impairment to dementia among subjects with diabetes: 
      a population-based study of incidence and risk factors with five years of 
      follow-up.
PG  - 1441-9
LID - 10.3233/JAD-141566 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with dementia. Mild cognitive 
      impairment (MCI) is a key determinant in this association. It is not clear 
      whether T2DM increases the risk of conversion from MCI to dementia. We plan to 
      explore the relationship between T2DM-MCI and dementia and identify its potential 
      risk factors. A prospective community-based cohort study was conducted from March 
      2010 to March 2014, including 634 participants with T2DM-MCI, 261 T2DM 
      participants who were cognitively intact, and 585 MCI participants without 
      diabetes. All cohort members received detailed annual evaluations to detect 
      dementia onset during the 5 years of follow-up. The three cohorts were compared 
      to assess differences in dementia onset. Furthermore, Cox proportional hazards 
      regression was used to identify risk factors for dementia onset in the T2DM-MCI 
      cohort. During follow-up, 152 and 49 subjects developed dementia in the MCI and 
      cognitively-intact cohorts, amounting to an adjusted hazard ratio (HR) of 1.66 
      (95% CI 1.07-2.26). In a survival analysis of the cohorts, MCI accelerated the 
      median progression to dementia by 2.74 years. In a multivariable analysis of the 
      T2DM-MCI cohort, major risk factors for dementia were age >75 years and longer 
      durations of diabetes, while significantly reduced risks of dementia were 
      associated with oral hypoglycemic agents and HMG-CoA reductase inhibitors. 
      Insulin was not associated with significantly changed risk. T2DM-MCI may 
      aggravate the clinical picture as a concomitant factor. To minimize progression 
      to dementia, it may be worthwhile to target several modifiable diabetes-specific 
      features, such as the duration of disease, glycemic control, and antidiabetic 
      agents.
FAU - Ma, Fei
AU  - Ma F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Wu, Tianfeng
AU  - Wu T
AD  - Department of Nutrition and Food Science, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Miao, Rujuan
AU  - Miao R
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Xiao, Yan Yu
AU  - Xiao YY
AD  - Department of Nutrition and Food Science, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Zhang, Wenwen
AU  - Zhang W
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Huang, Guowei
AU  - Huang G
AD  - Department of Nutrition and Food Science, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cognitive Dysfunction/complications/*epidemiology/*physiopathology
MH  - Dementia/complications/*epidemiology/*physiopathology
MH  - Diabetes Complications/*epidemiology
MH  - Diabetes Mellitus/drug therapy/*epidemiology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
MH  - Hypoglycemic Agents/therapeutic use
MH  - Incidence
MH  - Longitudinal Studies
MH  - Male
MH  - Multivariate Analysis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Factors
MH  - Survival Analysis
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cohort study
OT  - mild cognitive impairment
OT  - risk factors
OT  - type 2 diabetes mellitus
EDAT- 2014/08/28 06:00
MHDA- 2015/08/19 06:00
CRDT- 2014/08/28 06:00
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - B2153181X3G08077 [pii]
AID - 10.3233/JAD-141566 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2015;43(4):1441-9. doi: 10.3233/JAD-141566.