PMID- 25160080
OWN - NLM
STAT- MEDLINE
DCOM- 20141224
LR  - 20221207
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 73
DP  - 2014 Dec
TI  - Racial differences in levels of serum lipids and effects of exposure to 
      persistent organic pollutants on lipid levels in residents of Anniston, Alabama.
PG  - 216-23
LID - S0160-4120(14)00247-5 [pii]
LID - 10.1016/j.envint.2014.07.022 [doi]
AB  - Serum lipid levels are major risk factors for cardiovascular disease. In addition 
      to diet, exercise, genetics, age and race, serum concentrations of persistent 
      organic pollutants (POPs) influence concentrations of serum lipids. We 
      investigated associations between fasting concentrations of 35 polychlorinated 
      biphenyl (PCB) congeners and nine organochlorine pesticides in relation to total 
      serum lipids, total cholesterol, low-density lipoprotein (LDL) cholesterol, high 
      density lipoprotein (HDL) cholesterol and triglycerides in 525 Caucasian and 
      African American residents of Anniston, Alabama, who were not on any 
      lipid-lowering medication. In Model 1, data were adjusted for age, age quadratic, 
      gender, BMI, alcohol consumption, smoking and exercise, while in Model 2, 
      additional adjustment was done for other POPs. As compared to Caucasians, African 
      Americans had lower levels of total lipids and triglycerides with higher 
      concentrations of HDL cholesterol, but higher concentrations of PCBs and 
      pesticides. Total pesticides were more strongly associated with elevations in 
      serum lipids than were total PCBs, and the associations were stronger in African 
      Americans. Total DDTs were not associated with serum lipids after adjustment for 
      other POPs in either racial group, while the strongest positive associations were 
      seen for hexachlorobenzene (HCB) in both racial groups. Racial differences in 
      lipid profiles, concentrations of POPs and associations between POP 
      concentrations and serum lipids are relevant to racial differences in rates of 
      cardiovascular disease.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Aminov, Zafar
AU  - Aminov Z
AD  - Institute for Health and the Environment, University at Albany, Rensselaer, NY 
      12144, United States. Electronic address: zafaruz979@gmail.com.
FAU - Haase, Richard
AU  - Haase R
AD  - Institute for Health and the Environment, University at Albany, Rensselaer, NY 
      12144, United States. Electronic address: rfhremote@aol.com.
FAU - Olson, James R
AU  - Olson JR
AD  - Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, United States. 
      Electronic address: jolson@buffalo.edu.
FAU - Pavuk, Marian
AU  - Pavuk M
AD  - Agency for Toxic Substances and Disease Registry, Atlanta, GA, United States. 
      Electronic address: fsh8@cdc.gov.
FAU - Carpenter, David O
AU  - Carpenter DO
AD  - Institute for Health and the Environment, University at Albany, Rensselaer, NY 
      12144, United States. Electronic address: dcarpenter@albany.edu.
CN  - Anniston Environmental Health Research Consortium
LA  - eng
GR  - 5U50TS473215/TS/ATSDR CDC HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20140820
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Pesticides)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Black or African American
MH  - Aged
MH  - Alabama
MH  - Cholesterol/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Lipids/*blood
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Middle Aged
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Risk Factors
MH  - Triglycerides/blood
MH  - White People
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Cholesterol
OT  - HDL
OT  - PCBs
OT  - Pesticides
OT  - Triglycerides
FIR - Baker, Shirley
IR  - Baker S
FIR - Bartell, Scott
IR  - Bartell S
FIR - Olson, James
IR  - Olson J
FIR - Foushee, Russell
IR  - Foushee R
FIR - Percy, Alan
IR  - Percy A
FIR - Carpenter, David O
IR  - Carpenter DO
FIR - Cash, Jane
IR  - Cash J
FIR - Lavender, Martha
IR  - Lavender M
FIR - Shelton, Christie
IR  - Shelton C
FIR - Frumkin, Howard
IR  - Frumkin H
FIR - Pavuk, Marian
IR  - Pavuk M
FIR - Rosenbaum, Paula
IR  - Rosenbaum P
FIR - Silverstone, Allen
IR  - Silverstone A
FIR - Weinstock, Ruth
IR  - Weinstock R
FIR - Moysich, Kirsten
IR  - Moysich K
EDAT- 2014/08/28 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/08/28 06:00
PHST- 2014/03/27 00:00 [received]
PHST- 2014/06/24 00:00 [revised]
PHST- 2014/07/24 00:00 [accepted]
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - S0160-4120(14)00247-5 [pii]
AID - 10.1016/j.envint.2014.07.022 [doi]
PST - ppublish
SO  - Environ Int. 2014 Dec;73:216-23. doi: 10.1016/j.envint.2014.07.022. Epub 2014 Aug 
      20.