PMID- 25160294
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20140827
IS  - 1879-8365 (Electronic)
IS  - 0926-9630 (Linking)
VI  - 205
DP  - 2014
TI  - The use of DRG for identifying clinical trials centers with high recruitment 
      potential: a feasability study.
PG  - 783-7
AB  - Recruitment of large samples of patients is crucial for evidence level and 
      efficacy of clinical trials (CT). Clinical Trial Recruitment Support Systems 
      (CTRSS) used to estimate patient recruitment are generally specific to Hospital 
      Information Systems and few were evaluated on a large number of trials. Our aim 
      was to assess, on a large number of CT, the usefulness of commonly available data 
      as Diagnosis Related Groups (DRG) databases in order to estimate potential 
      recruitment. We used the DRG database of a large French multicenter medical 
      institution (1.2 million inpatient stays and 400 new trials each year). 
      Eligibility criteria of protocols were broken down into in atomic entities 
      (diagnosis, procedures, treatments...) then translated into codes and operators 
      recorded in a standardized form. A program parsed the forms and generated 
      requests on the DRG database. A large majority of selection criteria could be 
      coded and final estimations of number of eligible patients were close to observed 
      ones (median difference = 25). Such a system could be part of the feasability 
      evaluation and center selection process before the start of the clinical trial.
FAU - Aegerter, Philippe
AU  - Aegerter P
AD  - AP-HP, Hopital A. Pare, Unite de Recherche Clinique, Boulogne, France.
FAU - Bendersky, Noelle
AU  - Bendersky N
AD  - AP-HP, Hopital A. Pare, Unite de Recherche Clinique, Boulogne, France.
FAU - Tran, Thi-Chien
AU  - Tran TC
AD  - AP-HP, Hopital A. Pare, Unite de Recherche Clinique, Boulogne, France.
FAU - Ropers, Jacques
AU  - Ropers J
AD  - AP-HP, Hopital A. Pare, Unite de Recherche Clinique, Boulogne, France.
FAU - Taright, Namik
AU  - Taright N
AD  - AP-HP, Departement d'Information Medicale, Paris, France.
FAU - Chatellier, Gilles
AU  - Chatellier G
AD  - AP-HP, Hopital G. Pompidou, Unite de Recherche Clinique, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Clinical Trials as Topic/*methods/*statistics & numerical data
MH  - Diagnosis-Related Groups/*classification
MH  - Electronic Health Records/*classification/statistics & numerical data
MH  - France
MH  - *Health Records, Personal
MH  - *Natural Language Processing
MH  - *Patient Selection
EDAT- 2014/08/28 06:00
MHDA- 2015/05/16 06:00
CRDT- 2014/08/28 06:00
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2014;205:783-7.