PMID- 25161100
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20220316
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 28
IP  - 6
DP  - 2014 Nov-Dec
TI  - Risk characterization for urinary tract infections in subjects with newly 
      diagnosed type 2 diabetes.
PG  - 805-10
LID - S1056-8727(14)00189-5 [pii]
LID - 10.1016/j.jdiacomp.2014.06.009 [doi]
AB  - AIM: To evaluate the risk of urinary tract infections (UTI) in subjects with 
      newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: Subjects aged >/=18years 
      and diagnosed with T2DM between 1/1/10 and 12/31/10 were identified using the 
      MarketScan(R) databases, which are representative of the commercially insured US 
      population and those with both Medicare and supplemental coverage. The index date 
      was the first T2DM diagnosis date in 2010 (date randomly selected for those 
      without T2DM). Subjects without T2DM were matched (1:1) by index date, age, 
      gender, urban/rural location, and region. All subjects had continuous enrollment 
      for 12 months before (baseline) and after (follow-up) the index date. UTI 
      diagnosis was defined using ICD-9-CM codes. Measurements of glycemic control and 
      body weight were not available. An adjusted logistic regression model assessed 
      the likelihood of UTI. RESULTS: A total of 89,790 matched pairs were selected. 
      During follow-up, a UTI diagnosis was more common in subjects with T2DM than 
      without T2DM (9.4% vs. 5.7%; p<0.0001). Recurrence of UTI was also more likely 
      with T2DM (1.6% vs. 0.6%; p<0.0001). In a logistic regression, subjects with T2DM 
      had a greater likelihood of UTI during follow up (adjusted odds ratio [OR]=1.54 
      [95% CI: 1.47-1.60]). This relationship remained after stratifying by gender. 
      CONCLUSION: Subjects with T2DM were more likely to experience a UTI and recurrent 
      UTIs than subjects without T2DM during follow-up.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Fu, Alex Z
AU  - Fu AZ
AD  - Georgetown University Medical Center, Washington, DC.
FAU - Iglay, Kristy
AU  - Iglay K
AD  - Merck & Co., Inc., Whitehouse Station, NJ. Electronic address: 
      kristy.iglay@merck.com.
FAU - Qiu, Ying
AU  - Qiu Y
AD  - Merck & Co., Inc., Whitehouse Station, NJ.
FAU - Engel, Samuel
AU  - Engel S
AD  - Merck & Co., Inc., Whitehouse Station, NJ.
FAU - Shankar, Ravi
AU  - Shankar R
AD  - Merck & Co., Inc., Whitehouse Station, NJ.
FAU - Brodovicz, Kimberly
AU  - Brodovicz K
AD  - Merck & Co., Inc., Whitehouse Station, NJ.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140617
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/complications/diagnosis/*epidemiology
MH  - Diabetic Nephropathies/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - United States/epidemiology
MH  - Urinary Tract Infections/*epidemiology/etiology
MH  - Young Adult
OTO - NOTNLM
OT  - Cystitis
OT  - Pyelonephritis
OT  - Recurrent infections
OT  - Risk factors
OT  - Type 2 diabetes mellitus
OT  - Urinary tract infections
EDAT- 2014/08/28 06:00
MHDA- 2015/08/25 06:00
CRDT- 2014/08/28 06:00
PHST- 2014/01/08 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/06/10 00:00 [accepted]
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
AID - S1056-8727(14)00189-5 [pii]
AID - 10.1016/j.jdiacomp.2014.06.009 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2014 Nov-Dec;28(6):805-10. doi: 
      10.1016/j.jdiacomp.2014.06.009. Epub 2014 Jun 17.