PMID- 25162718
OWN - NLM
STAT- MEDLINE
DCOM- 20150421
LR  - 20140828
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 26
IP  - 11
DP  - 2014 Sep
TI  - The National Environmental Respiratory Center (NERC) experiment in 
      multi-pollutant air quality health research: I. Background, experimental strategy 
      and critique.
PG  - 643-50
LID - 10.3109/08958378.2014.923546 [doi]
AB  - The National Environmental Respiratory Center Program was initiated as an 
      experiment to explore strategies for identifying the components of complex air 
      pollution mixtures that cause health effects associated statistically with air 
      pollution. A strategy involving multivariate analysis of a 
      composition-concentration-response database was adopted. A novel database was 
      created by exposing rodents daily for up to six months to one of four 
      combustion-related mixtures and measuring respiratory, cardiovascular and general 
      toxicological responses after one week or six months of exposure. The mixtures 
      included multiple concentrations of diesel and gasoline engine exhaust, hardwood 
      smoke and simulated downwind coal combustion emissions. After reporting the 
      biological effects of each mixture and comparing effects among them, 47 
      significant effects were selected for multiple additive regression tree analysis 
      to identify putative causal components. Although the four mixtures provided a 
      database marginally sufficient for the analysis, the results suggested the 
      putative causes of 19 significant effects with acceptable confidence. This 
      article describes and critiques the Program and its strategy. The integrated 
      results are presented in two accompanying papers, and mixture-specific results 
      were presented in preceding papers, which are cited. The experiment demonstrated 
      the potential utility of the general approach and identified certain cause-effect 
      relationships for confirmatory studies. A follow-up study provided support for 
      causation by the components implicated for one of those relationships. The 
      advantages and disadvantages of the Program's management and funding strategies 
      are discussed.
FAU - Mauderly, Joe L
AU  - Mauderly JL
AD  - Lovelace Respiratory Research Institute , Albuquerque, NM , USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Complex Mixtures)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Air Pollution/*adverse effects
MH  - Complex Mixtures/*adverse effects
MH  - Environmental Exposure/adverse effects/analysis
MH  - Environmental Monitoring
MH  - Humans
MH  - Particulate Matter/analysis/toxicity
MH  - Research/*standards
MH  - United States
OTO - NOTNLM
OT  - Air pollution
OT  - coal emissions
OT  - diesel exhaust
OT  - gasoline exhaust
OT  - mixtures
OT  - multipollutant
OT  - regression tree
OT  - wood smoke
EDAT- 2014/08/28 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/08/28 06:00
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - 10.3109/08958378.2014.923546 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2014 Sep;26(11):643-50. doi: 10.3109/08958378.2014.923546.