PMID- 25162719
OWN - NLM
STAT- MEDLINE
DCOM- 20150421
LR  - 20140828
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 26
IP  - 11
DP  - 2014 Sep
TI  - The National Environmental Respiratory Center (NERC) experiment in 
      multi-pollutant air quality health research: II. Comparison of responses to 
      diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal 
      emissions.
PG  - 651-67
LID - 10.3109/08958378.2014.925523 [doi]
AB  - The NERC Program conducted identically designed exposure-response studies of the 
      respiratory and cardiovascular responses of rodents exposed by inhalation for up 
      to 6 months to diesel and gasoline exhausts (DE, GE), wood smoke (WS) and 
      simulated downwind coal emissions (CE). Concentrations of the four 
      combustion-derived mixtures ranged from near upper bound plausible to common 
      occupational and environmental hotspot levels. An "exposure effect" statistic was 
      created to compare the strengths of exposure-response relationships and 
      adjustments were made to minimize false positives among the large number of 
      comparisons. All four exposures caused statistically significant effects. No 
      exposure caused overt illness, neutrophilic lung inflammation, increased 
      circulating micronuclei or histopathology of major organs visible by light 
      microscopy. DE and GE caused the greatest lung cytotoxicity. WS elicited the most 
      responses in lung lavage fluid. All exposures reduced oxidant production by 
      unstimulated alveolar macrophages, but only GE suppressed stimulated macrophages. 
      Only DE retarded clearance of bacteria from the lung. DE before antigen challenge 
      suppressed responses of allergic mice. CE tended to amplify allergic responses 
      regardless of exposure order. GE and DE induced oxidant stress and 
      pro-atherosclerotic responses in aorta; WS and CE had no such effects. No overall 
      ranking of toxicity was plausible. The ranking of exposures by number of 
      significant responses varied among the response models, with each of the four 
      causing the most responses for at least one model. Each exposure could also be 
      deemed most or least toxic depending on the exposure metric used for comparison. 
      The database is available for additional analyses.
FAU - Mauderly, J L
AU  - Mauderly JL
AD  - Lovelace Respiratory Research Institute , Albuquerque, NM , USA .
FAU - Barrett, E G
AU  - Barrett EG
FAU - Day, K C
AU  - Day KC
FAU - Gigliotti, A P
AU  - Gigliotti AP
FAU - McDonald, J D
AU  - McDonald JD
FAU - Harrod, K S
AU  - Harrod KS
FAU - Lund, A K
AU  - Lund AK
FAU - Reed, M D
AU  - Reed MD
FAU - Seagrave, J C
AU  - Seagrave JC
FAU - Campen, M J
AU  - Campen MJ
FAU - Seilkop, S K
AU  - Seilkop SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Coal)
RN  - 0 (Gasoline)
RN  - 0 (Smoke)
RN  - 0 (Vehicle Emissions)
SB  - IM
MH  - Air Pollutants/*analysis/toxicity
MH  - Animals
MH  - Coal/*analysis
MH  - Gasoline/adverse effects/*analysis
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Random Allocation
MH  - Rats
MH  - Smoke/adverse effects/*analysis
MH  - United States
MH  - Vehicle Emissions/*analysis/toxicity
MH  - *Wood
OTO - NOTNLM
OT  - Air pollution
OT  - coal emissions
OT  - diesel exhaust
OT  - gasoline exhaust
OT  - inhalation
OT  - wood smoke
EDAT- 2014/08/28 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/08/28 06:00
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - 10.3109/08958378.2014.925523 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2014 Sep;26(11):651-67. doi: 10.3109/08958378.2014.925523.