PMID- 25162721
OWN - NLM
STAT- MEDLINE
DCOM- 20150421
LR  - 20140828
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 26
IP  - 11
DP  - 2014 Sep
TI  - The National Environmental Respiratory Center (NERC) experiment in 
      multi-pollutant air quality health research: IV. Vascular effects of repeated 
      inhalation exposure to a mixture of five inorganic gases.
PG  - 691-6
LID - 10.3109/08958378.2014.947448 [doi]
AB  - An experiment was conducted to test the hypothesis that a mixture of five 
      inorganic gases could reproduce certain central vascular effects of repeated 
      inhalation exposure of apolipoprotein E-deficient mice to diesel or gasoline 
      engine exhaust. The hypothesis resulted from preceding multiple additive 
      regression tree (MART) analysis of a composition-concentration-response database 
      of mice exposed by inhalation to the exhausts and other complex mixtures. The 
      five gases were the predictors most important to MART models best fitting the 
      vascular responses. Mice on high-fat diet were exposed 6 h/d, 7 d/week for 50 d 
      to clean air or a mixture containing 30.6 ppm CO, 20.5 ppm NO, 1.4 ppm NO(2), 
      0.5 ppm SO(2), and 2.0 ppm NH(3) in air. The gas concentrations were below the maxima 
      in the preceding studies but in the range of those in exhaust exposure levels 
      that caused significant effects. Five indicators of stress and 
      pro-atherosclerotic responses were measured in aortic tissue. The exposure 
      increased all five response indicators, with the magnitude of effect and 
      statistical significance varying among the indicators and depending on inclusion 
      or exclusion of an apparent outlying control. With the outlier excluded, three 
      responses approximated predicted values and two fell below predictions. The 
      results generally supported evidence that the five gases drove the effects of 
      exhaust, and thus supported the potential of the MART approach for identifying 
      putative causal components of complex mixtures.
FAU - Mauderly, J L
AU  - Mauderly JL
AD  - Lovelace Respiratory Research Institute , Albuquerque, NM , USA .
FAU - Kracko, D
AU  - Kracko D
FAU - Brower, J
AU  - Brower J
FAU - Doyle-Eisele, M
AU  - Doyle-Eisele M
FAU - McDonald, J D
AU  - McDonald JD
FAU - Lund, A K
AU  - Lund AK
FAU - Seilkop, S K
AU  - Seilkop SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Gases)
RN  - 0 (Gasoline)
RN  - 0 (Oxides)
RN  - 0 (Sulfur Compounds)
RN  - 0 (Vehicle Emissions)
RN  - 13827-32-2 (sulfur monoxide)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 7664-41-7 (Ammonia)
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - K50XQU1029 (Nitrous Oxide)
SB  - IM
MH  - Air Pollutants/*chemistry/toxicity
MH  - Ammonia/chemistry/toxicity
MH  - Animals
MH  - Apolipoproteins E/genetics/metabolism
MH  - Carbon Monoxide/chemistry/toxicity
MH  - Cardiovascular Diseases/*chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Gases/*chemistry/toxicity
MH  - Gasoline/*analysis
MH  - Mice
MH  - Mice, Knockout
MH  - Nitric Oxide/chemistry/toxicity
MH  - Nitrous Oxide/chemistry/toxicity
MH  - Oxides/chemistry/toxicity
MH  - Sulfur Compounds/chemistry/toxicity
MH  - Vehicle Emissions/*analysis/toxicity
OTO - NOTNLM
OT  - Air pollution
OT  - ammonia
OT  - carbon monoxide
OT  - cardiovascular
OT  - nitric oxide
OT  - nitrogen dioxide
OT  - nitrogen oxides
OT  - sulfur dioxide
EDAT- 2014/08/28 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/08/28 06:00
PHST- 2014/08/28 06:00 [entrez]
PHST- 2014/08/28 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - 10.3109/08958378.2014.947448 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2014 Sep;26(11):691-6. doi: 10.3109/08958378.2014.947448.