PMID- 25164257
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20211021
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Feb 28
TI  - Cathelicidin antimicrobial peptide as a serologic marker and potential pathogenic 
      factor in antineutrophil cytoplasmic antibody-associated vasculitis.
PG  - 105
AB  - Antineutrophil cytoplasmic antibodies are associated with pauci-immune 
      small-vessel vasculitis and crescentic glomerulonephritis. Cathelicidin LL37 is 
      the human member of a family of antimicrobial peptides that are released from 
      activated neutrophils and monocytes at sites of acute inflammation. Zhang and 
      colleagues evaluated serum levels of cathelicidin LL37 and interferon-alpha in 
      patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and 
      glomerulonephritis. Increased levels of cathelicidin LL37 and interferon-alpha 
      were associated with AAV patients, particularly those with glomerular crescent 
      formation. Cathelicidin LL37 may also be involved in the pathogenesis of AAV and 
      thus could be a target for novel therapy. Cathelicidin LL37 is a promising new 
      biomarker for active AAV, including aggressive crescentic glomerulonephritis, and 
      may prove to be both a prognostic marker and a guide for treatment.
FAU - Gasim, Adil
AU  - Gasim A
LA  - eng
PT  - Comment
PT  - Editorial
DEP - 20140228
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (Cathelicidins)
RN  - 0 (Peptide Fragments)
SB  - IM
CON - Arthritis Res Ther. 2013;15(5):R161. PMID: 24286516
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*blood
MH  - Cathelicidins/*blood
MH  - Female
MH  - Glomerulonephritis/*complications
MH  - Humans
MH  - Male
MH  - Peptide Fragments/*blood
PMC - PMC3978818
EDAT- 2014/08/29 06:00
MHDA- 2015/05/20 06:00
PMCR- 2014/02/28
CRDT- 2014/08/29 06:00
PHST- 2014/08/29 06:00 [entrez]
PHST- 2014/08/29 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PHST- 2014/02/28 00:00 [pmc-release]
AID - ar4495 [pii]
AID - 10.1186/ar4495 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2014 Feb 28;16(1):105. doi: 10.1186/ar4495.