PMID- 25164569
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20211021
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 52
IP  - 1
DP  - 2015 Aug
TI  - Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress 
      Induced by Ouabain in an Animal Model of Mania.
PG  - 353-62
LID - 10.1007/s12035-014-8873-8 [doi]
AB  - Several studies have suggested that alterations in brain-derived neurotrophic 
      factor (BDNF) and increased oxidative stress have a central role in bipolar 
      disorder (BD). Intracerebroventricular (ICV) injection of ouabain (OUA) in rats 
      alters oxidative stress parameters and decreases BDNF levels in the brain. In 
      this context, the present study aims to investigate the effects of BDNF ICV 
      administration on BDNF levels and oxidative stress parameters in brains of rats 
      submitted to animal model of mania induced by OUA. Wistar rats received an ICV 
      injection of OUA, artificial cerebrospinal fluid (ACSF), OUA plus BDNF, or ACSF 
      plus BDNF. Locomotor activity and risk-taking behavior in the rats were measured 
      using the open-field test. In addition, we analyzed the BDNF levels and oxidative 
      stress parameters (TBARS, Carbonyl, CAT, SOD, GR, and GPx) in the frontal cortex 
      and hippocampus of rats. The BDNF was unable to reverse the ouabain-induced 
      hyperactivity and risk-taking behavior. Nevertheless, BDNF treatment increased 
      BDNF levels, modulated the antioxidant enzymes, and protected the OUA-induced 
      oxidative damage in the brain of rats. These results suggest that BDNF alteration 
      observed in BD patients may be associated with oxidative damage, both seen in 
      this disorder.
FAU - Valvassori, Samira S
AU  - Valvassori SS
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      88806-000, Criciuma, SC, Brazil, samirasv@yahoo.com.br.
FAU - Arent, Camila O
AU  - Arent CO
FAU - Steckert, Amanda V
AU  - Steckert AV
FAU - Varela, Roger B
AU  - Varela RB
FAU - Jornada, Luciano K
AU  - Jornada LK
FAU - Tonin, Paula T
AU  - Tonin PT
FAU - Budni, Josiane
AU  - Budni J
FAU - Mariot, Edemilson
AU  - Mariot E
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Quevedo, Joao
AU  - Quevedo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140828
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 5ACL011P69 (Ouabain)
SB  - IM
MH  - Animals
MH  - Bipolar Disorder/*drug therapy/*pathology/physiopathology
MH  - Brain/drug effects/*pathology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage/*therapeutic use
MH  - Disease Models, Animal
MH  - Hippocampus/enzymology/pathology
MH  - Humans
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuroprotection
MH  - Ouabain
MH  - *Oxidative Stress/drug effects
MH  - Rats, Wistar
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2014/08/29 06:00
MHDA- 2016/05/03 06:00
CRDT- 2014/08/29 06:00
PHST- 2014/06/24 00:00 [received]
PHST- 2014/08/18 00:00 [accepted]
PHST- 2014/08/29 06:00 [entrez]
PHST- 2014/08/29 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
AID - 10.1007/s12035-014-8873-8 [pii]
AID - 10.1007/s12035-014-8873-8 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015 Aug;52(1):353-62. doi: 10.1007/s12035-014-8873-8. Epub 2014 
      Aug 28.