PMID- 25165412
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20211021
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2014
DP  - 2014
TI  - Effect of the Toll-like receptor 4 antagonist eritoran on retinochoroidal 
      inflammatory damage in a rat model of endotoxin-induced inflammation.
PG  - 643525
LID - 10.1155/2014/643525 [doi]
LID - 643525
AB  - PURPOSE: We investigated the effect of eritoran, a Toll-like receptor 4 
      antagonist, on retinochoroidal inflammatory damage in an endotoxin-induced 
      inflammatory rat model. METHODS: Endotoxin-induced inflammatory model was 
      obtained by intraperitoneal injection of 1.5 mg/kg lipopolysaccharide (LPS). 
      Group 1 had control rats; in groups 2-3 LPS and 0.5 mg/kg sterile saline were 
      injected; and in groups 4-5 LPS and 0.5 mg/kg eritoran were injected. Blood 
      samples were taken and eyes were enucleated after 12 hours (h) (groups 2 and 4) 
      or 24 hours (Groups 3 and 5). Tumor necrosis factor-alpha (TNF-alpha) and malondialdehyde 
      (MDA) levels in the serum and retinochoroidal tissue and nuclear factor kappa-B 
      (NFkappaB) levels in retinochoroidal tissue were determined. Histopathological 
      examination was performed and retinochoroidal changes were scored. RESULTS: 
      Eritoran treatment resulted in lower levels of TNF-alpha, MDA, and NFkappaB after 12 h 
      which became significant after 24 h. Serum TNF-alpha and retinochoroidal tissue NFkappaB 
      levels were similar to control animals at the 24th h of the study. Eritoran 
      significantly reversed histopathological damage after 24 h. CONCLUSIONS: Eritoran 
      treatment resulted in less inflammatory damage in terms of serum and 
      retinochoroidal tissue parameters.
FAU - Ekici, Feyzahan
AU  - Ekici F
AUID- ORCID: 0000-0002-3050-0714
AD  - Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, 
      53020 Rize, Turkey.
FAU - Karaca, Emine Esra
AU  - Karaca EE
AD  - Department of Ophthalmology, Sorgun State Hospital, 66700 Yozgat, Turkey.
FAU - Korkmaz, Safak
AU  - Korkmaz S
AD  - Department of Ophthalmology, Duzce State Hospital, 81100 Duzce, Turkey.
FAU - Yuksel, Osman
AU  - Yuksel O
AD  - Department of General Surgery, Gazi University Medical School, 06560 Ankara, 
      Turkey.
FAU - Gulbahar, Ozlem
AU  - Gulbahar O
AD  - Department of Medical Biochemistry, Gazi University Medical School, 06560 Ankara, 
      Turkey.
FAU - Alper, Murat
AU  - Alper M
AD  - Department of Pathology, Diskapi Training and Research Hospital, 06330 Ankara, 
      Turkey.
FAU - Ercan, Sevim
AU  - Ercan S
AD  - Department of Medical Pharmacology, Gazi University Medical School, 06560 Ankara, 
      Turkey.
FAU - Or, Meral
AU  - Or M
AD  - Department of Ophthalmology, Gazi University Medical School, 06560 Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140617
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Disaccharides)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Sugar Phosphates)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 551541VI0Y (eritoran)
SB  - IM
MH  - Animals
MH  - Disaccharides/*therapeutic use
MH  - Inflammation/*chemically induced/*drug therapy/metabolism
MH  - Lipopolysaccharides/*toxicity
MH  - Male
MH  - Malondialdehyde/blood/metabolism
MH  - NF-kappa B/blood/metabolism
MH  - Rats
MH  - Sugar Phosphates/*therapeutic use
MH  - Toll-Like Receptor 4/*antagonists & inhibitors
MH  - Tumor Necrosis Factor-alpha/blood/metabolism
PMC - PMC4084615
EDAT- 2014/08/29 06:00
MHDA- 2015/05/16 06:00
PMCR- 2014/06/17
CRDT- 2014/08/29 06:00
PHST- 2014/03/23 00:00 [received]
PHST- 2014/05/29 00:00 [revised]
PHST- 2014/05/29 00:00 [accepted]
PHST- 2014/08/29 06:00 [entrez]
PHST- 2014/08/29 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
PHST- 2014/06/17 00:00 [pmc-release]
AID - 10.1155/2014/643525 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2014;2014:643525. doi: 10.1155/2014/643525. Epub 2014 Jun 17.