PMID- 25168141
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140903
LR  - 20140829
IS  - 1063-5823 (Print)
IS  - 1063-5823 (Linking)
VI  - 59
DP  - 2007
TI  - Lipid stress at play: mechanosensitivity of voltage-gated channels.
PG  - 297-338
LID - S1063-5823(06)59011-8 [pii]
LID - 10.1016/S1063-5823(06)59011-8 [doi]
AB  - Membrane stretch modulates the activity of voltage-gated channels (VGCs). These 
      channels are nearly ubiquitous among eukaryotes and they are present, too, in 
      prokaryotes, so the potential ramifications of VGC mechanosensitivity are 
      diverse. In situ traumatic stretch can irreversibly alter VGC activity with 
      lethal results but that is pathology. This chapter discusses the reversible 
      responses of VGCs to stretch, with the general relation of stretch stimuli to 
      other forms of lipid stress, and briefly, with some irreversible stretch effects 
      (=stretch trauma). A working assumption throughout is that mechanosensitive (MS) 
      VGC motions-that is, motions that respond reversibly to bilayer stretch-are 
      susceptible to other forms of lipid stress, such as the stresses produced when 
      amphiphilic molecules (anesthetics, lipids, alcohols, and lipophilic drugs) are 
      inserted into the bilayer. Insofar as these molecules change the bilayer's 
      lateral pressure profile, they can be termed bilayer mechanical reagents (BMRs). 
      The chapter also discusses the MS VGC behavior against the backdrop of eukaryotic 
      channels more widely accepted as "MS channels"--namely, the transient receptor 
      potential (TRP)-based MS cation channels.
CI  - (c) 2007, Elsevier Inc. All right reserved.
FAU - Morris, Catherine E
AU  - Morris CE
AD  - Neuroscience, Ottawa Health Research Institute, Ottawa Hospital, Ottawa, Ontario 
      K1Y 4E9, Canada.
FAU - Juranka, Peter F
AU  - Juranka PF
AD  - Neuroscience, Ottawa Health Research Institute, Ottawa Hospital, Ottawa, Ontario 
      K1Y 4E9, Canada.
LA  - eng
PT  - Journal Article
DEP - 20070417
PL  - United States
TA  - Curr Top Membr
JT  - Current topics in membranes
JID - 9212591
EDAT- 2007/01/01 00:00
MHDA- 2007/01/01 00:01
CRDT- 2014/08/30 06:00
PHST- 2014/08/30 06:00 [entrez]
PHST- 2007/01/01 00:00 [pubmed]
PHST- 2007/01/01 00:01 [medline]
AID - S1063-5823(06)59011-8 [pii]
AID - 10.1016/S1063-5823(06)59011-8 [doi]
PST - ppublish
SO  - Curr Top Membr. 2007;59:297-338. doi: 10.1016/S1063-5823(06)59011-8. Epub 2007 
      Apr 17.