PMID- 25168240
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20211021
IS  - 1476-5403 (Electronic)
IS  - 1350-9047 (Print)
IS  - 1350-9047 (Linking)
VI  - 22
IP  - 2
DP  - 2015 Feb
TI  - Role and therapeutic value of dendritic cells in central nervous system 
      autoimmunity.
PG  - 215-24
LID - 10.1038/cdd.2014.125 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that control the 
      generation of adaptive immunity. Consequently, DCs have a central role in the 
      induction of protective immunity to pathogens and also in the pathogenic immune 
      response responsible for the development and progression of autoimmune disorders. 
      Thus the study of the molecular pathways that control DC development and function 
      is likely to result in new strategies for the therapeutic manipulation of the 
      immune response. In this review, we discuss the role and therapeutic value of DCs 
      in autoimmune diseases, with a special focus on multiple sclerosis.
FAU - Quintana, F J
AU  - Quintana FJ
AD  - Department of Neurology, Center for Neurologic Diseases, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, USA.
FAU - Yeste, A
AU  - Yeste A
AD  - Department of Neurology, Center for Neurologic Diseases, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, USA.
FAU - Mascanfroni, I D
AU  - Mascanfroni ID
AD  - Department of Neurology, Center for Neurologic Diseases, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, MA, USA.
LA  - eng
GR  - R56 AI093903/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140829
PL  - England
TA  - Cell Death Differ
JT  - Cell death and differentiation
JID - 9437445
RN  - 0 (Interleukin-27)
SB  - IM
MH  - Adaptive Immunity
MH  - Antigen-Presenting Cells/*immunology
MH  - Autoimmune Diseases/immunology
MH  - *Autoimmunity
MH  - Central Nervous System/*immunology
MH  - Dendritic Cells/classification/*immunology
MH  - Humans
MH  - Interleukin-27/immunology
MH  - Multiple Sclerosis/*immunology
MH  - Vaccination
PMC - PMC4291485
EDAT- 2014/08/30 06:00
MHDA- 2015/08/04 06:00
PMCR- 2016/02/01
CRDT- 2014/08/30 06:00
PHST- 2014/06/12 00:00 [received]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2014/08/30 06:00 [entrez]
PHST- 2014/08/30 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - cdd2014125 [pii]
AID - 10.1038/cdd.2014.125 [doi]
PST - ppublish
SO  - Cell Death Differ. 2015 Feb;22(2):215-24. doi: 10.1038/cdd.2014.125. Epub 2014 
      Aug 29.