PMID- 25170032
OWN - NLM
STAT- MEDLINE
DCOM- 20150818
LR  - 20220330
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 41
IP  - 1
DP  - 2015 Jan
TI  - Abnormal causal connectivity by structural deficits in first-episode, drug-naive 
      schizophrenia at rest.
PG  - 57-65
LID - 10.1093/schbul/sbu126 [doi]
AB  - Anatomical deficits and resting-state functional connectivity (FC) alterations in 
      prefrontal-thalamic-cerebellar circuit have been implicated in the neurobiology 
      of schizophrenia. However, the effect of structural deficits in schizophrenia on 
      causal connectivity of this circuit remains unclear. This study was conducted to 
      examine the causal connectivity biased by structural deficits in first-episode, 
      drug-naive schizophrenia patients. Structural and resting-state functional 
      magnetic resonance imaging (fMRI) data were obtained from 49 first-episode, 
      drug-naive schizophrenia patients and 50 healthy controls. Data were analyzed by 
      voxel-based morphometry and Granger causality analysis. The causal connectivity 
      of the integrated prefrontal-thalamic (limbic)-cerebellar (sensorimotor) circuit 
      was partly affected by structural deficits in first-episode, drug-naive 
      schizophrenia as follows: (1) unilateral prefrontal-sensorimotor connectivity 
      abnormalities (increased driving effect from the left medial prefrontal cortex 
      [MPFC] to the sensorimotor regions); (2) bilateral limbic-sensorimotor 
      connectivity abnormalities (increased driving effect from the right anterior 
      cingulate cortex [ACC] to the sensorimotor regions and decreased feedback from 
      the sensorimotor regions to the right ACC); and (3) bilateral increased and 
      decreased causal connectivities among the sensorimotor regions. Some correlations 
      between the gray matter volume of the seeds, along with their causal effects and 
      clinical variables (duration of untreated psychosis and symptom severity), were 
      also observed in the patients. The findings indicated the partial effects of 
      structural deficits in first-episode, drug-naive schizophrenia on the 
      prefrontal-thalamic (limbic)-cerebellar (sensorimotor) circuit. Schizophrenia may 
      reinforce the driving connectivities from the left MPFC or right ACC to the 
      sensorimotor regions and may disrupt bilateral causal connectivities among the 
      sensorimotor regions.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of the Maryland 
      Psychiatric Research Center. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, China; guowenbin76@163.com.
FAU - Liu, Feng
AU  - Liu F
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu, Sichuan, China;
FAU - Liu, Jianrong
AU  - Liu J
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, China;
FAU - Yu, Liuyu
AU  - Yu L
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, China;
FAU - Zhang, Jian
AU  - Zhang J
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, China;
FAU - Zhang, Zhikun
AU  - Zhang Z
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, China;
FAU - Xiao, Changqing
AU  - Xiao C
AD  - Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, 
      Nanning, China;
FAU - Zhai, Jinguo
AU  - Zhai J
AD  - School of Mental Health, Jining Medical University, Jining, China;
FAU - Zhao, Jingping
AU  - Zhao J
AD  - Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of 
      Psychiatry and Mental Health of Hunan Province, Central South University, 
      Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140828
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/pathology/physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Causality
MH  - Cerebellum/*pathology/physiopathology
MH  - Female
MH  - Functional Neuroimaging
MH  - Gyrus Cinguli/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/*pathology/physiopathology
MH  - Prefrontal Cortex/*pathology/physiopathology
MH  - Schizophrenia/*pathology/physiopathology
MH  - Thalamus/*pathology/physiopathology
MH  - Young Adult
PMC - PMC4266300
OTO - NOTNLM
OT  - Granger causality analysis
OT  - causal effect
OT  - first-episode schizophrenia
OT  - structural deficits
OT  - voxel-based morphometry
EDAT- 2014/08/30 06:00
MHDA- 2015/08/19 06:00
PMCR- 2016/01/01
CRDT- 2014/08/30 06:00
PHST- 2014/08/30 06:00 [entrez]
PHST- 2014/08/30 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - sbu126 [pii]
AID - 10.1093/schbul/sbu126 [doi]
PST - ppublish
SO  - Schizophr Bull. 2015 Jan;41(1):57-65. doi: 10.1093/schbul/sbu126. Epub 2014 Aug 
      28.