PMID- 25172294
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20211021
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Print)
IS  - 0959-8049 (Linking)
VI  - 50
IP  - 16
DP  - 2014 Nov
TI  - Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible 
      role for vascular epithelial growth factor A.
PG  - 2855-65
LID - S0959-8049(14)00874-0 [pii]
LID - 10.1016/j.ejca.2014.07.022 [doi]
AB  - BACKGROUND: Mechanisms involved in wound healing play some role in carcinogenesis 
      in multiple organs, likely by creating a chronic inflammatory milieu. This study 
      sought to assess the role of genetic markers in selected inflammation-related 
      genes involved in wound healing (interleukin (IL)-1a, IL-1b, IL-1 Receptor type I 
      (IL-1Ra), IL-1 Receptor type II (IL-1Rb), tumour necrosis factor (TNF)-alpha, tumour 
      necrosis factor receptor superfamily member (TNFRSF)1A, nuclear factor kappa beta 
      (NF-kB)1, NF-kB2, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, 
      hypoxia induced factor (HIF)-1alpha, vascular endothelial growth factor (VEGF)A and 
      P-53) in risk to oesophageal squamous cell carcinoma (OSCC). METHODS: We 
      genotyped 125 tag single nucleotide polymorphism (SNP)s in 410 cases and 377 age 
      and sex matched disease-free individuals from Nutritional Intervention Trial 
      (NIT) cohort, and 546 cases and 556 controls individually matched for age, sex 
      and neighbourhood from Shanxi case-control study, both conducted in high-risk 
      areas of north-central China (1985-2007). Cox proportional-hazard models and 
      conditional logistic regression models were used for SNPs analyses for NIT and 
      Shanxi, respectively. Fisher's inverse test statistics were used to obtain 
      gene-level significance. RESULTS: Multiple SNPs were significantly associated 
      with OSCC in both studies, however, none retained their significance after a 
      conservative Bonferroni adjustment. Empiric p-values for tag SNPs in VEGFA in NIT 
      were highly concentrated in the lower tail of the distribution, suggesting this 
      gene may be influencing risk. Permutation tests confirmed the significance of 
      this pattern. At the gene level, VEGFA yielded an empiric significance (P=0.027) 
      in NIT. We also observed some evidence for interaction between environmental 
      factors and some VEGFA tag SNPs. CONCLUSION: Our finding adds further evidence 
      for a potential role for markers in the VEGFA gene in the development and 
      progression of early precancerous lesions of oesophagus.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Golozar, Asieh
AU  - Golozar A
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD, USA. Electronic address: agolozar@jhu.edu.
FAU - Beaty, Terri H
AU  - Beaty TH
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Gravitt, Patti E
AU  - Gravitt PE
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Ruczinski, Ingo
AU  - Ruczinski I
AD  - Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Qiao, You-Lin
AU  - Qiao YL
AD  - Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of 
      Medical Sciences, Beijing, People's Republic of China.
FAU - Fan, Jin-Hu
AU  - Fan JH
AD  - Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of 
      Medical Sciences, Beijing, People's Republic of China.
FAU - Ding, Ti
AU  - Ding T
AD  - Shanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China.
FAU - Tang, Ze-Zhong
AU  - Tang ZZ
AD  - Shanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China.
FAU - Etemadi, Arash
AU  - Etemadi A
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Hu, Nan
AU  - Hu N
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Hyland, Paula L
AU  - Hyland PL
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Wang, Lemin
AU  - Wang L
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Wang, Chaoyu
AU  - Wang C
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Dawsey, Sanford M
AU  - Dawsey SM
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Freedman, Neal D
AU  - Freedman ND
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Abnet, Christian C
AU  - Abnet CC
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Goldstein, Alisa M
AU  - Goldstein AM
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
FAU - Taylor, Philip R
AU  - Taylor PR
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Bethesda, MD, USA.
LA  - eng
GR  - Z01 CP000112-03/Intramural NIH HHS/United States
GR  - Z01 CP000150-03/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20140826
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*epidemiology/*metabolism
MH  - Case-Control Studies
MH  - China
MH  - Cohort Studies
MH  - Esophageal Neoplasms/*epidemiology/*metabolism
MH  - Esophagus/metabolism
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Genotype
MH  - Humans
MH  - Inflammation
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Proportional Hazards Models
MH  - Quality Control
MH  - Reproducibility of Results
MH  - Vascular Endothelial Growth Factor A/*metabolism
PMC - PMC4363989
MID - NIHMS624582
OTO - NOTNLM
OT  - Genetic marker
OT  - Genetics
OT  - Inflammation
OT  - Inflammation-related events
OT  - Oesophageal squamous cell carcinoma
OT  - VEGFA
OT  - Vascular endothelial growth factor A
OT  - Wound-healing
COIS- Conflict of interest statement: None declared.
EDAT- 2014/08/31 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/11/01
CRDT- 2014/08/31 06:00
PHST- 2014/01/15 00:00 [received]
PHST- 2014/07/24 00:00 [revised]
PHST- 2014/07/29 00:00 [accepted]
PHST- 2014/08/31 06:00 [entrez]
PHST- 2014/08/31 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - S0959-8049(14)00874-0 [pii]
AID - 10.1016/j.ejca.2014.07.022 [doi]
PST - ppublish
SO  - Eur J Cancer. 2014 Nov;50(16):2855-65. doi: 10.1016/j.ejca.2014.07.022. Epub 2014 
      Aug 26.