PMID- 25172786
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20140830
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 21
IP  - 11
DP  - 2014 Sep 25
TI  - Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid 
      peroxidation in mouse brain.
PG  - 1249-55
LID - S0944-7113(14)00261-X [pii]
LID - 10.1016/j.phymed.2014.06.012 [doi]
AB  - Miroestrol (MR) is a phytoestrogen isolated from Pueraria candollei var. mirifica 
      (KwaoKrueaKhao), a Thai medicinal plant used for rejuvenation. We examined the 
      effects of MR on cognitive function, oxidative brain damage, and the expression 
      of genes encoding brain-derived neurotrophic factor (BDNF) and cyclic 
      AMP-responsive element-binding protein (CREB), factors implicated in neurogenesis 
      and synaptic plasticity, in ovariectomized (OVX) mice. OVX decreased serum 
      17beta-estradiol level and uterine weight. OVX also impaired object recognition 
      performance in the novel object recognition test and spatial cognitive 
      performance in the Y-maze test and the water maze test. Daily treatment of MR 
      dose-dependently attenuated OVX-induced cognitive dysfunction. Moreover, OVX mice 
      had a significantly increased level of thiobarbituric acid-reactive substances, 
      and down-regulated expression levels of BDNF and CREB mRNAs in the hippocampus 
      and frontal cortex. MR treatment as well as hormone replacement therapy with 
      17beta-estradiol significantly reversed these neurochemical alterations caused by 
      OVX. These results suggest that MR ameliorates cognitive deficits in OVX animals 
      via attenuation of OVX-induced oxidative stress and down-regulation of BDNF and 
      CREB mRNA transcription in the brain. Our findings raise the possibility that MR 
      and Pueraria candollei var. mirifica, the plant of origin of MR, may have a 
      beneficial effect on cognitive deficits like AD in which menopause/ovariectomy 
      are implicated as risk factors.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Monthakantirat, Orawan
AU  - Monthakantirat O
AD  - Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon 
      Kaen University, Khon Kaen, Thailand.
FAU - Sukano, Wichitsak
AU  - Sukano W
AD  - Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon 
      Kaen University, Khon Kaen, Thailand.
FAU - Umehara, Kaoru
AU  - Umehara K
AD  - Department of Pharmacognosy, School of Pharmaceutical Sciences, University of 
      Shizuoka, Yada 52-1, Shizuoka-shi, Shizuoka 422-8526, Japan.
FAU - Noguchi, Hiroshi
AU  - Noguchi H
AD  - Department of Pharmacognosy, School of Pharmaceutical Sciences, University of 
      Shizuoka, Yada 52-1, Shizuoka-shi, Shizuoka 422-8526, Japan.
FAU - Chulikhit, Yaowared
AU  - Chulikhit Y
AD  - Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon 
      Kaen University, Khon Kaen, Thailand; Division of Medicinal Pharmacology, 
      Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 
      930-0194, Japan. Electronic address: yaosum@kku.ac.th.
FAU - Matsumoto, Kinzo
AU  - Matsumoto K
AD  - Division of Medicinal Pharmacology, Institute of Natural Medicine, University of 
      Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140725
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Steroids)
RN  - 0 (miroestrol)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*drug effects
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Estradiol/blood
MH  - Female
MH  - Lipid Peroxidation/*drug effects
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Ovariectomy
MH  - Plant Bark/chemistry
MH  - Pueraria/*chemistry
MH  - Steroids/*pharmacology
MH  - Uterus/drug effects
OTO - NOTNLM
OT  - Cognitive dysfunction
OT  - Miroestrol
OT  - Ovariectomy
OT  - Oxidative stress
OT  - Pueraria candollei var. mirifica
EDAT- 2014/08/31 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/08/31 06:00
PHST- 2014/01/29 00:00 [received]
PHST- 2014/04/29 00:00 [revised]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/08/31 06:00 [entrez]
PHST- 2014/08/31 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S0944-7113(14)00261-X [pii]
AID - 10.1016/j.phymed.2014.06.012 [doi]
PST - ppublish
SO  - Phytomedicine. 2014 Sep 25;21(11):1249-55. doi: 10.1016/j.phymed.2014.06.012. 
      Epub 2014 Jul 25.