PMID- 25173051
OWN - NLM
STAT- MEDLINE
DCOM- 20150203
LR  - 20141209
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 134
DP  - 2014 Oct
TI  - Persistent organic pollutants are related to the change in circulating lipid 
      levels during a 5 year follow-up.
PG  - 190-7
LID - S0013-9351(14)00262-X [pii]
LID - 10.1016/j.envres.2014.08.005 [doi]
AB  - When reporting circulating levels of persistent organic pollutants (POPs), 
      usually lipid-normalized values are given. However, animal experiments and some 
      human data indicate that exposure to POPs may change lipid values. The aim of the 
      present study is to investigate if POP levels can predict future changes in 
      levels of circulating lipids. In the population-based Prospective Investigation 
      of the Vasculature in Uppsala Seniors (PIVUS) study, lipids were measured at age 
      70 and at age 75 in 598 subjects without lipid-lowering medication. Twenty-three 
      different POPs, including 16 polychlorinated biphenyls (PCBs), five 
      organochlorine pesticides, one dioxin (OCDD) and one flame retardant brominated 
      compound (BDE47) were analyzed by high-resolution chromatography coupled to 
      high-resolution mass spectrometry (HRGC/HRMS) at age 70. Strong relationships 
      were seen among the baseline levels of the non-dioxin-like PCBs 194, 206 and 209 
      and the degree of increase in total serum cholesterol and LDL-cholesterol during 
      the 5 year follow-up. These relationships were generally stronger when 
      lipid-normalized levels were used compared to wet-weight based levels. On the 
      contrary, for two of the pesticides, hexachlorobenzene and trans-nonachlordane, 
      levels were inversely related to the change in LDL-cholesterol, with strongest 
      associations found using wet-weight based levels. PCBs 194, 206 and 209 were 
      inversely related to the change in HDL-cholesterol, in particular for wet-weight 
      based levels. However, these relationships were only significant for wet-weight 
      PCB 194 following adjustment for multiple testing. None of the POPs was related 
      to the change in serum triglycerides. When investigating the association between 
      the change in total serum cholesterol and LDL-cholesterol across different 
      categories of change in BMI, we noted robust results especially in the group with 
      stable BMI, suggesting that the observed relationships were not due to 
      fluctuations in BMI over time. In conclusion, POPs are related to the change in 
      lipids over time, especially LDL-cholesterol. This may explain why POP exposure 
      previously has been linked to atherosclerosis and cardiovascular disease.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Penell, Johanna
AU  - Penell J
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, SE-751 85 Uppsala, Sweden.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Cardiovascular epidemiology, Uppsala University, 
      Uppsala, Sweden.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - van Bavel, Bert
AU  - van Bavel B
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, SE-751 85 Uppsala, Sweden. Electronic address: 
      monica.lind@medsci.uu.se.
LA  - eng
PT  - Journal Article
DEP - 20140828
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Aged
MH  - Environmental Pollutants/*blood
MH  - Follow-Up Studies
MH  - Humans
MH  - Lipids/*blood
MH  - Organic Chemicals/*blood
OTO - NOTNLM
OT  - Lipid-normalized
OT  - Lipids
OT  - Persistent organic pollutants
OT  - Prospective
OT  - Wet-weight
EDAT- 2014/09/01 06:00
MHDA- 2015/02/04 06:00
CRDT- 2014/09/01 06:00
PHST- 2013/06/14 00:00 [received]
PHST- 2014/07/02 00:00 [revised]
PHST- 2014/08/05 00:00 [accepted]
PHST- 2014/09/01 06:00 [entrez]
PHST- 2014/09/01 06:00 [pubmed]
PHST- 2015/02/04 06:00 [medline]
AID - S0013-9351(14)00262-X [pii]
AID - 10.1016/j.envres.2014.08.005 [doi]
PST - ppublish
SO  - Environ Res. 2014 Oct;134:190-7. doi: 10.1016/j.envres.2014.08.005. Epub 2014 Aug 
      28.