PMID- 25173085
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20211021
IS  - 1349-9157 (Electronic)
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 56
IP  - 1
DP  - 2015 Jan
TI  - Dosimetric benefits of placing dose constraints on the brachial plexus in 
      patients with nasopharyngeal carcinoma receiving intensity-modulated radiation 
      therapy: a comparative study.
PG  - 114-21
LID - 10.1093/jrr/rru072 [doi]
AB  - This study aimed to evaluate whether placing dose constraints on the brachial 
      plexus (BP) could provide dosimetric benefits in patients with nasopharyngeal 
      carcinoma (NPC) undergoing intensity-modulated radiation therapy (IMRT). Planning 
      CT images for 30 patients with NPC treated with definitive IMRT were 
      retrospectively reviewed. Target volumes, the BP and other critical structures 
      were delineated; two separate IMRT plans were designed for each patient: one set 
      no restrictions for the BP; the other considered the BP as a critical structure 
      for which a maximum dose limit of </=66 Gy was set. No significant differences 
      between the two plans were observed in the conformity index, homogeneity index, 
      maximum dose to the planning target volumes (PTVs), minimum dose to the PTVs, 
      percentages of the volume of the PTVnx and PTVnd receiving more than 110% of the 
      prescribed dose, or percentages of the volume of the PTVs receiving 95% and > 93% 
      of the prescribed dose. Dose constraints significantly reduced the maximum dose, 
      mean dose, V45, V50, V54, V60, V66 and V70 to the BP. Dose constraints 
      significantly reduced the maximum dose to the BP, V45, V60 and V66 in both N0-1 
      and N2-3 disease; however, the magnitude of the dosimetric gain for each 
      parameter between N0-1 and N2-3 disease was not significantly different, except 
      for the V60 and V66. In conclusion, placing dose constraints on the BP can 
      significantly decrease the irradiated volume and dose, without compromising 
      adequate dose delivery to the target volume.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of The Japan 
      Radiation Research Society and Japanese Society for Radiation Oncology.
FAU - Jiang, Hailan
AU  - Jiang H
AD  - Department of Radiation Oncology, People's Hospital of Guangxi Zhuang Autonomous 
      Region, 6 Taoyuan Road, Nanning City, 530021, Guangxi, P. R. China.
FAU - Lu, Heming
AU  - Lu H
AD  - Department of Radiation Oncology, People's Hospital of Guangxi Zhuang Autonomous 
      Region, 6 Taoyuan Road, Nanning City, 530021, Guangxi, P. R. China 
      luhming3632@163.com.
FAU - Yuan, Hong
AU  - Yuan H
AD  - Department of Otorhinolaryngology, People's Hospital of Guangxi Zhuang Autonomous 
      Region, 6 Taoyuan Road, Nanning City, 530021, Guangxi, P. R. China.
FAU - Huang, Huixian
AU  - Huang H
AD  - Department of Oncology, Liuzhou Worker's Hospital, Liuzhou 545005, P. R. China.
FAU - Wei, Yinglin
AU  - Wei Y
AD  - Department of Radiation Oncology, People's Hospital of Guangxi Zhuang Autonomous 
      Region, 6 Taoyuan Road, Nanning City, 530021, Guangxi, P. R. China.
FAU - Zhang, Yanxian
AU  - Zhang Y
AD  - Department of Clinical Medicine, Guangxi Medical University, Nanning 530021, P. 
      R. China.
FAU - Liu, Xu
AU  - Liu X
AD  - Department of Clinical Medicine, Guangxi Medical University, Nanning 530021, P. 
      R. China.
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140830
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brachial Plexus/radiation effects
MH  - Brachial Plexus Neuropathies/*etiology/*prevention & control
MH  - Carcinoma
MH  - Humans
MH  - Middle Aged
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Organ Sparing Treatments/methods
MH  - Radiation Injuries/etiology/*prevention & control
MH  - Radiation Protection/methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Conformal/*adverse effects
MH  - Young Adult
PMC - PMC4572593
OTO - NOTNLM
OT  - brachial plexus
OT  - comparative study
OT  - dose constraints
OT  - intensity-modulated radiation therapy
OT  - nasopharyngeal carcinoma
OT  - radiation injury
EDAT- 2014/09/01 06:00
MHDA- 2015/09/26 06:00
PMCR- 2014/08/30
CRDT- 2014/09/01 06:00
PHST- 2014/09/01 06:00 [entrez]
PHST- 2014/09/01 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
PHST- 2014/08/30 00:00 [pmc-release]
AID - rru072 [pii]
AID - 10.1093/jrr/rru072 [doi]
PST - ppublish
SO  - J Radiat Res. 2015 Jan;56(1):114-21. doi: 10.1093/jrr/rru072. Epub 2014 Aug 30.