PMID- 25173454
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20141203
IS  - 1872-8111 (Electronic)
IS  - 0168-0102 (Linking)
VI  - 88
DP  - 2014 Nov
TI  - Chronic social instability stress enhances vulnerability of BDNF response to LPS 
      in the limbic structures of female rats: a protective role of antidepressants.
PG  - 74-83
LID - S0168-0102(14)00184-9 [pii]
LID - 10.1016/j.neures.2014.08.008 [doi]
AB  - The aim of the present study was to estimate the influence of antidepressants 
      given chronically on brain-derived neurotrophic factor (BDNF) alterations induced 
      by lipopolysaccharide (LPS) in the amygdala and hippocampus of female rats 
      subjected to chronic social instability stress (CSIS) for 29-30 days. CSIS was 
      used as a paradigm known to be more stressful for females because stress induces 
      affective disorders more frequently in women than men. An increased relative 
      adrenal weight and a tendency towards the enhanced plasma corticosterone 
      concentration were found in the stressed rats. Sucrose preference was not 
      changed. On the last experimental day, the rats in the estrus phase were injected 
      ip with LPS (1mg/kg). In the stressed rats, LPS administration decreased BDNF 
      mRNA levels in both limbic structures. Desipramine (10mg/kg), fluoxetine (5mg/kg) 
      or tianeptine (10mg/kg) given ip once daily reversed the effect of the combined 
      stress and LPS, and tianeptine induced the strongest effects. These results 
      indicate that chronic stress enhances vulnerability of BDNF response to 
      deleterious influence of neuroinflammation in the examined limbic structures, 
      what may account for its role in triggering neuropsychiatric diseases. The 
      observed effect of antidepressants may be of significance for their therapeutic 
      effects in the stress-induced affective disorders in females.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All 
      rights reserved.
FAU - Nowacka, Marta M
AU  - Nowacka MM
AD  - Department of Pharmacology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland; Laboratory of Molecular Biology, Faculty of 
      Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, 
      Poland; Center For Experimental Medicine, Katowice, Poland. Electronic address: 
      mnowacka@sum.edu.pl.
FAU - Paul-Samojedny, Monika
AU  - Paul-Samojedny M
AD  - Department of Medical Genetics, Faculty of Pharmacy in Sosnowiec, Medical 
      University of Silesia, Katowice, Poland.
FAU - Bielecka, Anna M
AU  - Bielecka AM
AD  - Department of Pharmacology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Obuchowicz, Ewa
AU  - Obuchowicz E
AD  - Department of Pharmacology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland. Electronic address: eobuchowicz@sum.edu.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140828
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Amygdala/drug effects/metabolism
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/blood
MH  - Disease Models, Animal
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Lipopolysaccharides/*pharmacology
MH  - Rats, Sprague-Dawley
MH  - *Social Behavior
MH  - Stress, Psychological/*metabolism/physiopathology
OTO - NOTNLM
OT  - Antidepressants
OT  - Brain derived-neurotrophic factor (BDNF)
OT  - Chronic social instability stress (CSIS)
OT  - Female rats
OT  - Lipopolysaccharide
EDAT- 2014/09/01 06:00
MHDA- 2015/09/15 06:00
CRDT- 2014/09/01 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/07/31 00:00 [revised]
PHST- 2014/08/21 00:00 [accepted]
PHST- 2014/09/01 06:00 [entrez]
PHST- 2014/09/01 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - S0168-0102(14)00184-9 [pii]
AID - 10.1016/j.neures.2014.08.008 [doi]
PST - ppublish
SO  - Neurosci Res. 2014 Nov;88:74-83. doi: 10.1016/j.neures.2014.08.008. Epub 2014 Aug 
      28.