PMID- 25173802
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20211021
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 155
IP  - 1
DP  - 2014 Nov
TI  - Modulation of dendritic cell innate and adaptive immune functions by oral and 
      sublingual immunotherapy.
PG  - 47-59
LID - S1521-6616(14)00197-1 [pii]
LID - 10.1016/j.clim.2014.08.006 [doi]
AB  - Sublingual (SLIT) and oral immunotherapy (OIT) are promising treatments for food 
      allergy, but underlying mechanisms are poorly understood. Dendritic cells (DCs) 
      induce and maintain Th2-type allergen-specific T cells, and also regulate innate 
      immunity through their expression of Toll-like receptors (TLRs). We examined how 
      SLIT and OIT influenced DC innate and adaptive immune responses in children with 
      IgE-mediated cow's milk (CM) allergy. SLIT, but not OIT, decreased TLR-induced 
      IL-6 secretion by myeloid DCs (mDCs). SLIT and OIT altered mDC IL-10 secretion, a 
      potent inhibitor of FcepsilonRI-dependent pro-inflammatory responses. OIT uniquely 
      augmented IFN-alpha and decreased IL-6 secretion by plasmacytoid DCs (pDCs), which 
      was associated with reduced TLR-induced IL-13 release in pDC-T cell co-cultures. 
      Both SLIT and OIT decreased Th2 cytokine secretion to CM in pDC-T, but not mDC-T, 
      co-cultures. Therefore, SLIT and OIT exert unique effects on DC-driven innate and 
      adaptive immune responses, which may inhibit allergic inflammation and promote 
      tolerance.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Frischmeyer-Guerrerio, Pamela A
AU  - Frischmeyer-Guerrerio PA
AD  - Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins 
      University School of Medicine, Baltimore, MD, USA. Electronic address: 
      pguerrerio@jhmi.edu.
FAU - Keet, Corinne A
AU  - Keet CA
AD  - Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins 
      University School of Medicine, Baltimore, MD, USA. Electronic address: 
      ckeet1@jhmi.edu.
FAU - Guerrerio, Anthony L
AU  - Guerrerio AL
AD  - Division of Gastroenterology, Department of Pediatrics, Johns Hopkins University 
      School of Medicine, Baltimore, MD, USA. Electronic address: aguerrerio@jhmi.edu.
FAU - Chichester, Kristin L
AU  - Chichester KL
AD  - Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins 
      University School of Medicine, Baltimore, MD, USA. Electronic address: 
      kchiches@jhmi.edu.
FAU - Bieneman, Anja P
AU  - Bieneman AP
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, Johns 
      Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: 
      abienema@jhmi.edu.
FAU - Hamilton, Robert G
AU  - Hamilton RG
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, Johns 
      Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: 
      rhamilto@jhmi.edu.
FAU - Wood, Robert A
AU  - Wood RA
AD  - Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins 
      University School of Medicine, Baltimore, MD, USA. Electronic address: 
      rwood@jhmi.edu.
FAU - Schroeder, John T
AU  - Schroeder JT
AD  - Division of Allergy and Clinical Immunology, Department of Medicine, Johns 
      Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: 
      schray@jhmi.edu.
LA  - eng
GR  - R21 HD073557/HD/NICHD NIH HHS/United States
GR  - 101872/PHS HHS/United States
GR  - K23AI091869/AI/NIAID NIH HHS/United States
GR  - K23 AI103187/AI/NIAID NIH HHS/United States
GR  - R21 AI079853/AI/NIAID NIH HHS/United States
GR  - R21AI079853/AI/NIAID NIH HHS/United States
GR  - K23 AI091869/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140827
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Peptidoglycan)
RN  - 0 (Receptors, IgE)
RN  - 0 (TLR2 protein, human)
RN  - 0 (Toll-Like Receptor 2)
SB  - IM
MH  - Administration, Oral
MH  - Administration, Sublingual
MH  - Adolescent
MH  - Allergens/*administration & dosage/*therapeutic use
MH  - Cells, Cultured
MH  - Child
MH  - Coculture Techniques
MH  - Cytokines/genetics/metabolism
MH  - Dendritic Cells
MH  - Double-Blind Method
MH  - Gene Expression Regulation/drug effects/immunology
MH  - Humans
MH  - Milk Hypersensitivity/*therapy
MH  - Peptidoglycan/pharmacology
MH  - Receptors, IgE/genetics/metabolism
MH  - T-Lymphocytes/immunology/physiology
MH  - Toll-Like Receptor 2/genetics/metabolism
PMC - PMC4252363
MID - NIHMS624659
OTO - NOTNLM
OT  - Adaptive immunity;
OT  - Dendritic cell;
OT  - Food allergy;
OT  - Immunotherapy;
OT  - Innate immunity;
OT  - Tolerance
EDAT- 2014/09/01 06:00
MHDA- 2015/01/27 06:00
PMCR- 2015/11/01
CRDT- 2014/09/01 06:00
PHST- 2014/04/15 00:00 [received]
PHST- 2014/08/16 00:00 [revised]
PHST- 2014/08/19 00:00 [accepted]
PHST- 2014/09/01 06:00 [entrez]
PHST- 2014/09/01 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - S1521-6616(14)00197-1 [pii]
AID - 10.1016/j.clim.2014.08.006 [doi]
PST - ppublish
SO  - Clin Immunol. 2014 Nov;155(1):47-59. doi: 10.1016/j.clim.2014.08.006. Epub 2014 
      Aug 27.