PMID- 25173889
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20220330
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 38
IP  - 1
DP  - 2015 Feb
TI  - Anti-inflammatory and membrane-stabilizing properties of two semisynthetic 
      derivatives of oleanolic acid.
PG  - 61-9
LID - 10.1007/s10753-014-0007-y [doi]
AB  - Acetylation and methylation semisynthesis of oleanolic acid (OA) isolated from 
      Syzygium aromaticum L. yielded two compounds: 3-acetoxyoleanolic acid (3-AOA) and 
      3-acetoxy, 28-methylester oleanolic acid (3-A,28-MOA). Anti-inflammatory 
      properties of these compounds were assessed using the serotonin and fresh egg 
      albumin-induced inflammatory test models in male Wistar rats weighing 250-300 g. 
      Furthermore, erythrocyte membrane-stabilizing property of these compounds was 
      evaluated in the heat- and hypotonicity-induced in vitro hemolysis test models. 
      The two semisynthetic compounds significantly (p < 0.05) inhibited 
      albumin-induced inflammation better than OA and indomethacin from 1-5 h post 
      administration. Both compounds were membrane stabilizing in heat-induced 
      hemolysis test while only 3-AOA showed membrane-stabilizing effects in a 
      hypotonic milieu. Semisynthesis of OA yielded two compounds which had better in 
      vivo anti-inflammatory and in vitro membrane-stabilizing properties.
FAU - Nkeh-Chungag, Benedicta N
AU  - Nkeh-Chungag BN
AD  - Department of Zoology, Faculty of Science, Engineering & Technology, PB X1, 
      Mthatha, 5117, Eastern Cape Province, South Africa, bnkehchungag@wsu.ac.za.
FAU - Oyedeji, Opeoluwa O
AU  - Oyedeji OO
FAU - Oyedeji, Adebola O
AU  - Oyedeji AO
FAU - Ndebia, Eugene J
AU  - Ndebia EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Plant Extracts)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/isolation & purification/*pharmacology
MH  - Cell Membrane/*drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hemolysis/drug effects/physiology
MH  - Humans
MH  - Male
MH  - Oleanolic Acid/chemistry/isolation & purification/*pharmacology
MH  - Plant Extracts/chemistry/isolation & purification/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - *Syzygium
EDAT- 2014/09/01 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/09/01 06:00
PHST- 2014/09/01 06:00 [entrez]
PHST- 2014/09/01 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s10753-014-0007-y [doi]
PST - ppublish
SO  - Inflammation. 2015 Feb;38(1):61-9. doi: 10.1007/s10753-014-0007-y.