PMID- 25174272
OWN - NLM
STAT- MEDLINE
DCOM- 20160229
LR  - 20200109
IS  - 1778-3585 (Electronic)
IS  - 0924-9338 (Linking)
VI  - 30
IP  - 1
DP  - 2015 Jan
TI  - Negative symptom subgroups have different effects on the clinical course of 
      schizophrenia after the first episode: a 24-month follow up study.
PG  - 14-9
LID - S0924-9338(14)00142-4 [pii]
LID - 10.1016/j.eurpsy.2014.07.005 [doi]
AB  - OBJECTIVE: The aim of this study was to assess the factor structure of negative 
      symptoms in first-episode schizophrenia (FES), and to examine the relationship of 
      these factors with clinical course and functioning of patients during the 
      two-year follow up. METHOD: We assessed 174 drug-naive patients with FES using 
      Brief Psychiatric Rating Scale-Expanded (BPRS), Scale for the Assessment of 
      Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), 
      and Global Assessment of Functioning (GAF) and a cognitive battery at admission. 
      The scales were repeated monthly during follow up. We recorded the patients' 
      functioning levels, remission, and work status after 12 and 24 months. RESULTS: A 
      two-factor structure was found at the baseline, whereas one factor was found 
      after 12 and 24 months. Expressive deficit (ED) factor consisted of alogia and 
      blunted affect, and motivation-pleasure deficit (MPD) factor consisted of 
      avolition and anhedonia. ED factor was related to earlier onset and remission, 
      and it was negatively correlated with duration of education and cognitive test 
      scores. MPD factor was related to duration of untreated psychosis, family history 
      of schizophrenia, and work status, and it appeared as the only independent 
      variable that contributed to the baseline GAF score in linear regression 
      analysis. CONCLUSION: Our findings suggest that the factors have different 
      aetiologies and impacts on the clinical course of schizophrenia and functioning 
      after FES.
CI  - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.
FAU - Ergul, C
AU  - Ergul C
AD  - Department of Psychiatry, Istanbul Faculty of Medicine, Istanbul University, 
      Millet Street, Capa, Fatih, Istanbul, Turkey.
FAU - Ucok, A
AU  - Ucok A
AD  - Department of Psychiatry, Istanbul Faculty of Medicine, Istanbul University, 
      Millet Street, Capa, Fatih, Istanbul, Turkey. Electronic address: 
      alpucok@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20140827
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
SB  - IM
MH  - Adult
MH  - Brief Psychiatric Rating Scale
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/psychology
MH  - Schizophrenia/drug therapy
MH  - *Schizophrenic Psychology
OTO - NOTNLM
OT  - BPRS
OT  - First episode schizophrenia
OT  - Negative symptoms
OT  - Neuropsychological tests
OT  - SANS
OT  - SAPS
EDAT- 2014/09/02 06:00
MHDA- 2016/03/02 06:00
CRDT- 2014/09/02 06:00
PHST- 2014/02/21 00:00 [received]
PHST- 2014/07/26 00:00 [revised]
PHST- 2014/07/27 00:00 [accepted]
PHST- 2014/09/02 06:00 [entrez]
PHST- 2014/09/02 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - S0924-9338(14)00142-4 [pii]
AID - 10.1016/j.eurpsy.2014.07.005 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2015 Jan;30(1):14-9. doi: 10.1016/j.eurpsy.2014.07.005. Epub 2014 
      Aug 27.