PMID- 25174839
OWN - NLM
STAT- MEDLINE
DCOM- 20150630
LR  - 20191113
IS  - 1873-4251 (Electronic)
IS  - 1570-162X (Linking)
VI  - 12
IP  - 5
DP  - 2014
TI  - 2 ,3 -Dialdehyde of ATP, ADP, and adenosine inhibit HIV-1 reverse transcriptase 
      and HIV-1 replication.
PG  - 347-58
AB  - The 2 3 -dialdehyde of ATP or oxidized ATP (oATP) is a compound known for 
      specifically making covalent bonds with the nucleotide-binding site of several 
      ATP-binding enzymes and receptors. We investigated the effects of oATP and other 
      oxidized purines on HIV-1 infection and we found that this compound inhibits 
      HIV-1 and SIV infection by blocking early steps of virus replication. oATP, 
      oxidized ADP (oADP), and oxidized Adenosine (oADO) impact the natural activity of 
      endogenous reverse transcriptase enzyme (RT) in cell free virus particles and are 
      able to inhibit viral replication in different cell types when added to the cell 
      cultures either before or after infection. We used UFLC-UV to show that both oADO 
      and oATP can be detected in the cell after being added in the extracellular 
      medium. oATP also suppresses RT activity and replication of the HIV-1 resistant 
      variants M184V and T215Y. We conclude that oATP, oADP and oADO display anti HIV-1 
      activity that is at in least in part due to inhibitory activity on HIV-1 RT.
FAU - Schachter, Julieta
AU  - Schachter J
FAU - Valadao, Ana Luiza Chaves
AU  - Valadao AL
FAU - Aguiar, Renato Santana
AU  - Aguiar RS
FAU - Barreto-de-Souza, Victor
AU  - Barreto-de-Souza V
FAU - Rossi, Atila Duque
AU  - Rossi AD
FAU - Arantes, Pablo Ricardo
AU  - Arantes PR
FAU - Verli, Hugo
AU  - Verli H
FAU - Quintana, Paula Gabriela
AU  - Quintana PG
FAU - Heise, Norton
AU  - Heise N
FAU - Tanuri, Amilcar
AU  - Tanuri A
FAU - Bou-Habib, Dumith Chequer
AU  - Bou-Habib DC
FAU - Persechini, Pedro Muanis
AU  - Persechini PM
AD  - Instituto de Biofisica, Carlos Chagas Filho (IBCCF), Universidade Federal do Rio 
      de Janeiro, Polo de Xerem, RJ, Brasil. julieta@biof.ufrj.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Curr HIV Res
JT  - Current HIV research
JID - 101156990
RN  - 0 (Anti-HIV Agents)
RN  - 54970-91-1 (2',3'-dialdehyde ATP)
RN  - 61D2G4IYVH (Adenosine Diphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.7.- (reverse transcriptase, Human immunodeficiency virus 1)
RN  - EC 2.7.7.49 (HIV Reverse Transcriptase)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/*pharmacology
MH  - Adenosine Diphosphate/*pharmacology
MH  - Adenosine Triphosphate/*analogs & derivatives/pharmacology
MH  - Anti-HIV Agents/*pharmacology
MH  - Cells, Cultured
MH  - HIV Infections/*drug therapy
MH  - HIV Reverse Transcriptase/*antagonists & inhibitors/metabolism
MH  - HIV-1/*drug effects/enzymology/physiology
MH  - Humans
MH  - Macrophages/virology
MH  - Virus Replication/*drug effects
EDAT- 2014/09/02 06:00
MHDA- 2015/07/01 06:00
CRDT- 2014/09/02 06:00
PHST- 2014/01/26 00:00 [received]
PHST- 2014/06/11 00:00 [revised]
PHST- 2014/08/15 00:00 [accepted]
PHST- 2014/09/02 06:00 [entrez]
PHST- 2014/09/02 06:00 [pubmed]
PHST- 2015/07/01 06:00 [medline]
AID - CHRE-EPUB-61960 [pii]
AID - 10.2174/1570162x12666140826105824 [doi]
PST - ppublish
SO  - Curr HIV Res. 2014;12(5):347-58. doi: 10.2174/1570162x12666140826105824.