PMID- 25174893
OWN - NLM
STAT- MEDLINE
DCOM- 20150204
LR  - 20141203
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 6
DP  - 2014 Dec
TI  - Paraneoplastic cloudy vitelliform submaculopathy in primary vitreoretinal 
      lymphoma.
PG  - 1253-1261.e2
LID - S0002-9394(14)00533-9 [pii]
LID - 10.1016/j.ajo.2014.08.031 [doi]
AB  - PURPOSE: To describe the nature and evolution of paraneoplastic cloudy 
      vitelliform submaculopathy in patients with primary vitreoretinal lymphoma and 
      propose a mechanism for its development and course. DESIGN: Retrospective, 
      observational case series. METHODS: Three patients presenting with unilateral 
      cloudy vitelliform submaculopathy based on clinical examination, fundus 
      autofluorescence, fluorescein angiography, and spectral-domain optical coherence 
      tomography (SD OCT) imaging and ultimately diagnosed with primary vitreoretinal 
      lymphoma and/or primary central nervous system lymphoma were analyzed. RESULTS: 
      In all 3 patients, cloudy vitelliform submaculopathy appeared with hazy 
      indistinct yellow subretinal material resembling the vitelliform lesions found in 
      acute exudative paraneoplastic polymorphous vitelliform maculopathy, although 
      with less distinct appearance and without intense hyper-autofluorescence. In all 
      3 patients, cloudy vitelliform submaculopathy was transient, showed spontaneous 
      regression within 3 months, and preceded the diagnosis of lymphoma, suggestive of 
      a paraneoplastic process. The diagnosis of primary vitreoretinal lymphoma and/or 
      primary central nervous system lymphoma was made within 6 months with classic 
      features of new intraretinal or sub-retinal pigment epithelium infiltration of 
      lymphoma in the peripheral retina (n = 2) and hyperintense lesions on brain 
      magnetic resonance imaging (n = 2). With SD OCT imaging, the cloudy vitelliform 
      subretinal lesions appeared as hyperreflective debris above the retinal pigment 
      epithelium band in all 3 eyes, and were associated with an irregularly thickened 
      and rippled retinal pigment epithelium band in 2 eyes. Resolution of the cloudy 
      submacular lesions resulted in outer retinal atrophic changes in all 3 eyes. 
      CONCLUSION: Paraneoplastic cloudy vitelliform submaculopathy, a form of 
      lymphoma-associated retinopathy, can precede the diagnosis of primary 
      vitreoretinal lymphoma or primary central nervous system lymphoma and can regress 
      spontaneously, leaving outer retinal abnormalities.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Pang, Claudine E
AU  - Pang CE
AD  - Vitreous Retina Macula Consultants of New York, New York, New York; LuEsther T. 
      Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, 
      New York. Electronic address: claudine.e.pang@gmail.com.
FAU - Shields, Carol L
AU  - Shields CL
AD  - Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 
      Philadelphia, Pennsylvania.
FAU - Jumper, J Michael
AU  - Jumper JM
AD  - West Coast Retina Medical Group, San Francisco, California.
FAU - Yannuzzi, Lawrence A
AU  - Yannuzzi LA
AD  - Vitreous Retina Macula Consultants of New York, New York, New York; LuEsther T. 
      Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, 
      New York; Department of Ophthalmology, New York University, New York, New York.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140828
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Optical Imaging
MH  - Paraneoplastic Syndromes/*diagnosis/physiopathology
MH  - Remission, Spontaneous
MH  - Retinal Neoplasms/*diagnosis/physiopathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Vitelliform Macular Dystrophy/*diagnosis/physiopathology
MH  - Vitreous Body/*pathology
EDAT- 2014/09/02 06:00
MHDA- 2015/02/05 06:00
CRDT- 2014/09/02 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/08/24 00:00 [revised]
PHST- 2014/08/25 00:00 [accepted]
PHST- 2014/09/02 06:00 [entrez]
PHST- 2014/09/02 06:00 [pubmed]
PHST- 2015/02/05 06:00 [medline]
AID - S0002-9394(14)00533-9 [pii]
AID - 10.1016/j.ajo.2014.08.031 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Dec;158(6):1253-1261.e2. doi: 10.1016/j.ajo.2014.08.031. 
      Epub 2014 Aug 28.