PMID- 2517537
OWN - NLM
STAT- MEDLINE
DCOM- 19900614
LR  - 20190828
IS  - 0015-5632 (Print)
IS  - 0015-5632 (Linking)
VI  - 34
IP  - 6
DP  - 1989
TI  - Loss of penicillin resistance in Paracoccus denitrificans induced by mitomycin C 
      and acridine orange.
PG  - 465-70
AB  - In an attempt to eliminate the penicillin resistance gene of P. dentrificans by 
      curing agents, such as acridine orange (AO) and mitomycin C, it was observed that 
      AO treatment caused temporary phenotypic curing where development of sensitivity 
      was a function of concentration of both the curing agent and benzylpenicillin. 
      However, curing with mitomycin produced sensitive clones at a frequency of 6 X 
      10(-3) and two permanently cured clones were isolated. Heavy metal resistance and 
      resistance to other drugs, however, remain unchanged in the mitomycin-cured 
      isolate.
FAU - Das, T K
AU  - Das TK
AD  - Department of Botany, Burdwan University, India.
FAU - Banerjee, A K
AU  - Banerjee AK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Folia Microbiol (Praha)
JT  - Folia microbiologica
JID - 0376757
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Mitomycins)
RN  - 0 (Penicillins)
RN  - 50SG953SK6 (Mitomycin)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*pharmacology
MH  - Anti-Bacterial Agents/pharmacology
MH  - Drug Resistance, Microbial
MH  - Mitomycin
MH  - Mitomycins/*pharmacology
MH  - Paracoccus denitrificans/*drug effects/genetics
MH  - Penicillins/*pharmacology
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/BF02814455 [doi]
PST - ppublish
SO  - Folia Microbiol (Praha). 1989;34(6):465-70. doi: 10.1007/BF02814455.