PMID- 25175688
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20201226
IS  - 1875-5992 (Electronic)
IS  - 1871-5206 (Linking)
VI  - 14
IP  - 8
DP  - 2014
TI  - Tapasin and human leukocyte antigen class I dysregulation correlates with 
      survival in glioblastoma multiforme.
PG  - 1101-9
AB  - Human leukocyte antigen class I (HLA-I) molecules present antigenic peptides to 
      cytotoxic CD8(+) T cells. Downregulation of peptide:HLA-I complexes is common in 
      tumors and results in tumor immune escape variants. Also molecules involved in 
      the maturation of HLA-I have been demonstrated to be dysregulated in malignant 
      neoplasms. We here set out to investigate the antigen presentation capabilities 
      of a set of 12 glioblastoma multiforme (GBM) tumors based on the expression of 
      HLA-I. Moreover, we analyzed the expression of tapasin, a protein dedicated and 
      essential to HLA-I maturation, as well as the infiltration of CD8+ cells using 
      immunohistochemistry on paraffin-embedded sections. Comparison of different GBMs 
      showed a variation in expression of both HLA-I heavy chain (HC) and tapasin. 
      Interestingly, the expression of tapasin and HLA-I HC correlated significantly 
      (p=0.0002) suggesting tapasin to be a key factor for efficient HLA-I antigen 
      presentation in GBMs. Although no statistically significant correlation between 
      CD8(+) cells and survival was found, probably due to a very low number of 
      infiltrating CD8(+) cells at the time of surgical resection, both tapasin and 
      HLA-I HC levels significantly correlated with survival. We suggest that analysis 
      of expression of tapasin and/or HLA-I may be of value as prognostic tool for GBM 
      patients, especially when considering immunotherapy.
FAU - Thuring, Camilla
AU  - Thuring C
FAU - Geironson, Linda
AU  - Geironson L
FAU - Paulsson, Kajsa
AU  - Paulsson K
AD  - Immunology, Lund University, BMC D14, 221 84 Lund, Sweden. 
      Kajsa_M.Paulsson@med.lu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Anticancer Agents Med Chem
JT  - Anti-cancer agents in medicinal chemistry
JID - 101265649
RN  - 0 (HLA Antigens)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (tapasin)
SB  - IM
MH  - Aged
MH  - Brain Neoplasms/metabolism/mortality/*pathology
MH  - CD8-Positive T-Lymphocytes/metabolism
MH  - Glioblastoma/metabolism/mortality/*pathology
MH  - HLA Antigens/genetics/*metabolism
MH  - Humans
MH  - Membrane Transport Proteins/genetics/*metabolism
MH  - Middle Aged
MH  - Survival Rate
EDAT- 2014/09/02 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/09/02 06:00
PHST- 2012/08/23 00:00 [received]
PHST- 2012/11/01 00:00 [revised]
PHST- 2013/09/11 00:00 [accepted]
PHST- 2014/09/02 06:00 [entrez]
PHST- 2014/09/02 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - ACAMC-EPUB-61893 [pii]
AID - 10.2174/1871520614666140825110402 [doi]
PST - ppublish
SO  - Anticancer Agents Med Chem. 2014;14(8):1101-9. doi: 
      10.2174/1871520614666140825110402.